Compartmental organization of the ventral striatum of the rat: immunohistochemical distribution of enkephalin, substance P, dopamine, and calcium-binding protein.

The Journal of Comparative Neurology
P VoornH J Groenewegen

Abstract

In the caudate-putamen of the rat a patch/matrix organization can be recognized on the basis of the immunohistochemical distribution of several markers, which include enkephalin, substance P, dopamine, and calcium-binding protein. In the present experiments the distributional relations of these markers were investigated in the nucleus accumbens. The distribution of enkephalin fibers shows different inhomogeneities according to their location in the nucleus. Rostrally, heavily labeled areas stand out against a moderately stained background, whereas caudally, in medial and ventral parts of the nucleus, lightly stained areas delineate regions in the moderately stained neuropil. In the distribution of substance P, areas with high staining intensity were observed in the medial and ventral parts of the nucleus accumbens. Inhomogeneities in the distribution of strong dopamine immunoreactivity consist of weakly immunoreactive areas throughout the rostrocaudal extent of the nucleus accumbens and extremely heavily labeled areas in the medial and ventral parts of the nucleus. Calcium-binding protein immunoreactivity can only be detected in dorsal parts of the nucleus. The generally intense immunostaining for calcium-binding protein is int...Continue Reading

References

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Citations

Feb 8, 2008·Brain Structure & Function·Gloria E MeredithAnn E Kelley
Apr 1, 1992·Trends in Neurosciences·C R Gerfen
Mar 1, 1995·Neurobiology of Aging·R D BurwellM Gallagher
Feb 5, 1993·Neuroscience Letters·H W Berendse, E K Richfield
Jan 1, 1989·Neuroscience·J Jiménez-Castellanos, A M Graybiel
Jan 1, 1992·Neuroscience·J C StoofH J Groenewegen

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