Compartmentalization and cyclic variation of immunoreactivity of renin and angiotensin converting enzyme in human endometrium throughout the menstrual cycle

Human Reproduction
X F Li, A Ahmed


Renin and angiotensin converting enzymes (ACE) are responsible for the generation of angiotensin II which regulates blood pressure and fluid/electrolyte homeostasis. The cellular localization and cyclic distribution of renin and ACE in human endometrium are demonstrated in this study. Immunohistochemical studies revealed that both renin and ACE were consistently localized in the endometrial glandular epithelia throughout the menstrual cycle; however, the immunostainings respectively for ACE and renin were weak and moderate in stromal cells of proliferative endometrium and negligible in secretory endometrium. No renin immunostaining was detected around endometrial blood vessels. Although endothelial cells consistently stained for ACE, no renin immunoreactivity was detected in these cells during the menstrual cycle. Western blot analysis using ACE antibody directed against human kidney identified a single protein band with a relative molecular mass of approximately 153 kDa. The intensity of this band showed cyclic variation during the menstrual cycle with the highest ACE expression during the late secretory phase and at menses suggesting that ACE plays a role in the initiation of menstruation. The differences in the cellular dist...Continue Reading


Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Lauren Anton, K Bridget Brosnihan
Jun 13, 2009·Endocrinology·Lauren AntonK Bridget Brosnihan
Jun 12, 2012·Journal of Molecular Histology·João Vaz-SilvaFernando M Reis
Aug 6, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Merit LampAndres Salumets
Nov 27, 2015·Reproductive Biology and Endocrinology : RB&E·Eugenie R LumbersKirsty G Pringle
Aug 15, 2000·Placenta·A H NielsenK Poulsen
Aug 10, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Lukas SchwentnerChristine Wulff
Feb 24, 2007·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Julie SandersDavid R Woods
Jul 4, 2006·Physiological Reviews·Martin PaulReinhold Kreutz
Aug 23, 2020·Cell Death & Disease·Shu-Yun LiZeng-Ming Yang
May 5, 2020·Molecular Human Reproduction·Yan JingChen Fei

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