Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition

Cell
Andreas DoncicJan M Skotheim

Abstract

Cells make accurate decisions in the face of molecular noise and environmental fluctuations by relying not only on present pathway activity, but also on their memory of past signaling dynamics. Once a decision is made, cellular transitions are often rapid and switch-like due to positive feedback loops in the regulatory network. While positive feedback loops are good at promoting switch-like transitions, they are not expected to retain information to inform subsequent decisions. However, this expectation is based on our current understanding of network motifs that accounts for temporal, but not spatial, dynamics. Here, we show how spatial organization of the feedback-driven yeast G1/S switch enables the transmission of memory of past pheromone exposure across this transition. We expect this to be one of many examples where the exquisite spatial organization of the eukaryotic cell enables previously well-characterized network motifs to perform new and unexpected signal processing functions.

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Citations

Nov 7, 2015·Molecular Biology of the Cell·Yoshikazu OhyaShinsuke Ohnuki
Jul 28, 2016·Cell Systems·Oguzhan AtayJan M Skotheim
Aug 26, 2016·Cell Systems·Christopher P MancusoAhmad S Khalil
Jan 4, 2017·The Journal of Cell Biology·Oguzhan Atay, Jan M Skotheim
Nov 11, 2017·The Journal of Biological Chemistry·Yang LiNan Hao
Oct 26, 2018·Molecular Biology of the Cell·Allison W McClureDaniel J Lew
Feb 25, 2020·Molecular Systems Biology·Angel StanoevAneta Koseska
May 14, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ryan SudermanEric J Deeds
Jan 8, 2021·PLoS Computational Biology·Jan Rombouts, Lendert Gelens
Feb 9, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Giovanni PezzuloMichael Levin
Feb 23, 2021·Current Opinion in Cell Biology·Polina Reichert, Fabrice Caudron
Sep 19, 2020·Molecular Cell·Seth M RubinJan M Skotheim
Sep 11, 2021·Nature Communications·Govind Menon, J Krishnan

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