Compartmentalization of drug resistance-associated mutations in a treatment-naive HIV-infected female

AIDS Research and Human Retroviruses
Grissell TiradoAnil Kumar

Abstract

Development of a drug-resistant variant of HIV-1 has been one of the major concerns contributing to the transmission of the virus. A 40-year-old woman presented to the clinic with micosis and oral candidiasis. The subject was referred for HIV-1 diagnosis. Subsequent investigations revealed a very low CD4 T cell count (48 cell/microl blood) and high plasma HIV-1 RNA load (4.33 x 10(5) copy/ml). A 1.3-kb pol fragment was sequenced in virus collected from plasma and the vaginal compartment. Plasma virus had no mutation in reverse transcriptase and one mutation in protease (L63P). On the other hand vaginal virus contained L63P and M184V mutations in protease and reverse transcriptase, respectively. These mutations were accompanied by several other mutations in previously identified CTL epitopic regions of the two genes. In the absence of antiretroviral treatment, a drug-resistant mutant was thought to develop because of immune pressure. This is the first report describing the role of immune pressure in the development of a drug-resistant virus.

References

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Citations

Apr 21, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·James HomansAndrea Kovacs
Jul 15, 2015·Computational and Mathematical Methods in Medicine·Miguel Arenas
Jan 13, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Babafemi Taiwo
Oct 14, 2009·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Uma ShanmugasundaramBalakrishnan Pachamuthu
Aug 13, 2011·The Cochrane Database of Systematic Reviews·Amita RayNarasimman Swaminathan
Oct 11, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·George OkafoEliseo A Eugenin

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