Compartmentalization Technologies via Self-Assembly and Cross-Linking of Amphiphilic Random Block Copolymers in Water

Journal of the American Chemical Society
Mayuko MatsumotoMitsuo Sawamoto

Abstract

Orthogonal self-assembly and intramolecular cross-linking of amphiphilic random block copolymers in water afforded an approach to tailor-make well-defined compartments and domains in single polymer chains and nanoaggregates. For a double compartment single-chain polymer, an amphiphilic random block copolymer bearing hydrophilic poly(ethylene glycol) (PEG) and hydrophobic dodecyl, benzyl, and olefin pendants was synthesized by living radical polymerization (LRP) and postfunctionalization; the dodecyl and benzyl units were incorporated into the different block segments, whereas PEG pendants were statistically attached along a chain. The copolymer self-folded via the orthogonal self-assembly of hydrophobic dodecyl and benzyl pendants in water, followed by intramolecular cross-linking, to form a single-chain polymer carrying double yet distinct hydrophobic nanocompartments. A single-chain cross-linked polymer with a chlorine terminal served as a globular macroinitiator for LRP to provide an amphiphilic tadpole macromolecule comprising a hydrophilic nanoparticle and a hydrophobic polymer tail; the tadpole thus self-assembled into multicompartment aggregates in water.

References

Aug 10, 2002·Science·Dennis E Discher, Adi Eisenberg
Oct 2, 2004·Science·Zhibo LiTimothy P Lodge
May 2, 2009·Journal of the American Chemical Society·E Johan FosterE W Meijer
Jun 30, 2009·Angewandte Chemie·Alexander V Kabanov, Serguei V Vinogradov
Aug 12, 2009·Chemical Reviews·Stijn F M van DongenJan C M van Hest
Nov 28, 2012·Journal of the American Chemical Society·Nobuhiko HosonoE W Meijer
Jul 19, 2014·Chemical Communications : Chem Comm·Longyu LiS Thayumanavan
Oct 28, 2015·Chemical Society Reviews·Marina Gonzalez-BurgosJosé A Pomposo
Nov 26, 2015·Macromolecular Rapid Communications·Ozcan Altintas, Christopher Barner-Kowollik
Jun 30, 2016·Nature Communications·Tina I LöblingAxel H E Müller

❮ Previous
Next ❯

Citations

Feb 16, 2021·Macromolecules·Thomas J NealOleksandr O Mykhaylyk
Apr 18, 2021·Macromolecular Rapid Communications·Meshari A M AlqarniC Remzi Becer
Jun 19, 2018·Journal of the American Chemical Society·Goki HattoriTakaya Terashima
Apr 25, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Natalya S VishnevetskayaChristine M Papadakis
Dec 7, 2018·Journal of the American Chemical Society·Shota ImaiTakaya Terashima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.