Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins.

Circulation Research
Kimberly L Dodge-KafkaJohn D Scott

Abstract

The activation of the cyclic nucleotide protein kinase A (PKA) and PKG by their respective second messengers is responsible for the modulation of many cellular functions in the heart including cardiac hypertrophy, strength of contraction, and ion flux. However, several studies have revealed that a general increase in cyclic nucleotide concentration in the cell is not sufficient for the specific regulation of target proteins. These studies found that PKA and PKG must be colocalized with their targets to ensure spatial-temporal control of substrate phosphorylation. This compartmentation of cyclic nucleotide signaling is accomplished by tethering the protein kinases with their respective substrates through the association with scaffolding proteins. For cAMP signaling, A-kinase anchoring proteins (AKAPs) provide a molecular mechanism for cAMP compartmentation, allowing for the precise control of PKA-mediated phosphorylation events. (cAMP, PKA, AKAP, PKG).

References

Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·J Jurevicius, R Fischmeister
Jan 1, 1995·Advances in Pharmacology·T M LincolnT L Cornwell
Jun 10, 1998·Biochemical and Biophysical Research Communications·N K VoV M Coghlan
Dec 18, 1998·Science·H KawasakiA M Graybiel
Feb 27, 1999·Current Opinion in Cell Biology·A Bretscher
Jun 4, 1999·Trends in Cell Biology·M Colledge, J D Scott
Dec 22, 1999·The Journal of Biological Chemistry·K YuasaN Yanaka
Jul 6, 2000·FEBS Letters·K Dodge, J D Scott
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·F PotetI Baró
Jan 24, 2002·Nature·Donald M Bers
Jan 24, 2002·Nature·Eduardo Marbán
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·Joseph A Beavo, Laurence L Brunton
Mar 26, 2003·The Journal of Biological Chemistry·Shawn M EllerbroekKeith Burridge
Apr 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Neal M AltoJohn D Scott
Jul 12, 2003·The Journal of Biological Chemistry·Nathan AirhartMichael Silberbach
Oct 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Joanne T HulmeWilliam A Catterall
Jun 9, 2004·The Biochemical Journal·Jennifer J Carlisle MichelJohn D Scott
Aug 18, 2004·Neurochemistry International·Claudio GrassiGian Battista Azzena
Sep 24, 2004·Molecular Cell·Graeme K CarnegieJohn D Scott

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Citations

Aug 6, 2008·The Journal of Membrane Biology·Yan LiThomas V McDonald
May 20, 2011·Current Heart Failure Reports·Magali BerthouzeFrank Lezoualc'h
Apr 3, 2012·Biologie aujourd'hui·Delphine MikaRodolphe Fischmeister
Oct 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Brian W JonesG Stanley McKnight
Jan 1, 2014·The Journal of General Physiology·Michael S KapiloffKimberly L Dodge-Kafka
Jan 1, 2014·The Journal of General Physiology·Marco ContiWito Richter
Dec 1, 2010·Protein Engineering, Design & Selection : PEDS·William A McLaughlinWei Wang
Oct 8, 2011·Journal of Cardiovascular Pharmacology·Riad Efendiev, Carmen W Dessauer
May 13, 2011·Journal of Cardiovascular Pharmacology·John M Redden, Kimberly L Dodge-Kafka
Sep 3, 2011·Journal of Cardiovascular Pharmacology·Lei Chen, Robert S Kass
Nov 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jonathan ChenJochen Buck
May 10, 2008·Circulation Research·David A Kass
Aug 19, 2009·PLoS Biology·Davide CalebiroMartin J Lohse
Apr 24, 2014·Pflügers Archiv : European journal of physiology·Aziz GuellichRodolphe Fischmeister
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lei ChenRobert S Kass
Dec 30, 2008·Heart Failure Reviews·Ali El-Armouche, Thomas Eschenhagen
Sep 20, 2006·Expert Opinion on Therapeutic Targets·Stephan E Lehnart, Andrew R Marks
Mar 5, 2015·International Journal of Molecular Medicine·Huixin GuoYidong Wei
Feb 10, 2007·The Journal of Physiology·Sunita WarrierRobert D Harvey
Dec 23, 2015·Cellular Signalling·Joana FeiteiroElisa Cairrão
Mar 3, 2012·European Journal of Pharmacology·Zachary M SellersPhilip M Best
Nov 4, 2011·Current Opinion in Pharmacology·Sanja BecaPeter H Backx
Mar 16, 2011·Cellular Signalling·Magali BrecklerFrank Lezoualc'h
Dec 7, 2010·Biochemical and Biophysical Research Communications·Shubai LiuYang K Xiang
Aug 7, 2010·Drug Discovery Today. Disease Models·Crystal F Kline, Peter J Mohler
Feb 19, 2008·Biochemical and Biophysical Research Communications·Rebecca C StrattonAnne K Green
Nov 13, 2007·Biochimica Et Biophysica Acta·Susan S TaylorNatarajan Kannan
Dec 1, 2015·Frontiers in Pharmacology·Silvio WeberAli El-Armouche
Oct 5, 2010·The FEBS Journal·Jeremy S Logue, John D Scott
Feb 7, 2013·Acta Physiologica·R K Perera, V O Nikolaev
Sep 6, 2011·Journal of Molecular and Cellular Cardiology·Delphine MikaRodolphe Fischmeister
May 15, 2007·Biochimica Et Biophysica Acta·Joseph G ReynoldsFrancisco J Naya

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