Compartments in the lamprey embryonic brain as revealed by regulatory gene expression and the distribution of reticulospinal neurons

Brain Research Bulletin
Yasunori MurakamiShigeru Kuratani

Abstract

The vertebrate neural tube consists of a series of neuromeres along its anteroposterior axis. Between amphioxus that possesses no neuromeres and gnathostomes, the lamprey occupies a critical position in the phylogeny for the origin of the segmented brain. To clarify the rhombomeric configuration of the Japanese lamprey, Lampetra japonica, we injected rhodamine- and fluorescein-labeled dextrans into the larval spinal cord, and retrogradely labeled the reticulospinal neurons. We also isolated prosomere marker genes from the embryonic cDNA library of L. japonica, and performed in situ hybridization on the embryonic brain. Of the genes examined, LjOtxA, LjPax6, LjPax2/5/8, LjDlx1/6, and LjTTF-1 were expressed in clearly demarcated polygonal domains. In the telencephalon, LjDlx1/6, LjPax6, and a putative paralogue of LjEmx were expressed in different domains; the LjEmx paralogue was expressed in the dorsal region, and LjDlx1/6 and LjPax6 in a complimentary fashion of the middle part. These expression patterns implied existence of a tripartite configuration of the lamprey telencephalon similar to that in gnathostomes. All these evidences strongly suggest that the segmental and compartmental architecture of the vertebrate brain was al...Continue Reading

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Citations

Jan 8, 2008·Science in China. Series C, Life Sciences·LiNa ZhuQingWei Li
Sep 8, 2005·Brain Research Bulletin·Begoña Villar-ChedaM Celina Rodicio
Mar 30, 2002·Brain Research Bulletin·Rudolf Nieuwenhuys
Jul 16, 2009·Evolution & Development·Elizabeth M TankJames A Langeland
Feb 17, 2010·Evolution & Development·Nobuhiro KokuboMikiko Tanaka
Mar 27, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ricardo Lara-RamírezSebastian M Shimeld
Jun 12, 2013·Journal of Neurogenetics·Lauren A O'Connell
Jun 28, 2011·Current Biology : CB·Marcus Stephenson-JonesSten Grillner
Aug 10, 2010·Developmental Biology·Yumie MurataMikiko Tanaka
Jul 23, 2004·The Journal of Comparative Neurology·Takahiro KageYuji Ishikawa
Dec 31, 2005·The Journal of Comparative Neurology·Begoña Villar-ChedaMaría Celina Rodicio
Sep 6, 2017·Development Genes and Evolution·Ricardo Lara-RamírezSebastian M Shimeld
Oct 24, 2002·Genesis : the Journal of Genetics and Development·Shigeru KurataniYasunori Murakami
Dec 27, 2005·Gene·Akiko Ogura NodaTakashi Gojobori

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