PMID: 9416382Jan 7, 1998Paper

Compatibility and stability of paclitaxel combined with cisplatin and with carboplatin in infusion solutions

The Annals of Pharmacotherapy
Y ZhangJ F Martinez

Abstract

To evaluate the physical compatibility and chemical stability of paclitaxel at concentrations of 0.3 and 1.2 mg/mL with cisplatin 0.2 mg/mL in NaCl 0.9% injection and with carboplatin 2 mg/mL in NaCl 0.9% injection and dextrose 5% injection over 7 days at 4, 23, and 32 degrees C. The test samples were prepared in polyolefin bags of the infusion solutions at the required drug concentrations. Evaluations were performed initially and after 4 hours, and 1, 3, 5, and 7 days of storage at temperatures of 4, 23, and 32 degrees C for physical and chemical stability. Physical stability was assessed by using visual observation in normal light and using a high-intensity monodirectional light beam. In addition, turbidity and particle content were measured electronically. Chemical stability of the three drugs was evaluated by using three stability-indicating HPLC analytical techniques. All samples were physically stable through 1 day. However, microcrystalline precipitation of paclitaxel occurred in 3 days in some samples and within 5 days in all samples. Paclitaxel concentrations remained above 90% in all samples throughout the study. Cisplatin admixtures exhibited paclitaxel concentration-dependent decomposition with cisplatin losses of a...Continue Reading

References

Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P B Schiff, S B Horwitz
Nov 1, 1981·The Journal of Cell Biology·J Parness, S B Horwitz
Jan 1, 1994·The Annals of Pharmacotherapy·A ChinL S DiMeglio
Apr 1, 1994·Journal of Clinical Pharmacy and Therapeutics·B BenajiJ C Cazin

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Citations

Sep 15, 2005·The Annals of Pharmacotherapy·Jean-Daniel HecqLaurence M Galanti
Oct 12, 2010·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshiaki OkamotoEtsuko Uejima

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