PMID: 15354785Sep 10, 2004Paper

Compatibility research of self-designed scaffold biomaterials of nature extracellular matrix

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
Yanjun WangShengbin Bi

Abstract

Scaffold biomaterials for cell culture of tissue-engineering demand satisfactory biocompatibility. This experiment aimed to evaluate biocompatibility of self-designed scaffold biomaterial of NECM. The biocompatibility of self-designed NECM was evaluated both in vivo and in vitro, including cytotoxic test, acute and subacute systemic toxicity test, hemolysis test, pyrogenic test, lymphocyte transformation test and long-term subcutaneous implantation test of NECM. Self-designed NECM scaffold biomaterial for cell culture has no cytotoxicity, no acute and subacute systemic toxicity, and it did not cause inflammatory reaction. Self-designed NECM has good biocompatibility and may become an ideal biological scaffold material for cell culture of tissue engineering.

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