Compensatory enlargement of a solitary functioning kidney during fetal development

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
Stefan H van VuurenTom P V M de Jong

Abstract

To determine the degree of compensatory enlargement, and its time of onset, of the solitary functioning kidney (SFK) in fetuses with unilateral renal agenesis (URA) or unilateral multicystic kidney dysplasia (MCKD). This was a retrospective study of fetuses with URA or MCKD diagnosed prenatally and confirmed postnatally in the period from January 1999 to May 2011. Fetuses with any other congenital anomalies were excluded. Measurements of kidney length were retrieved from our prenatal ultrasound database and a nomogram was established and compared with that for normal kidney length. In total, 67 fetuses were identified, 60 with MCKD and seven with URA, for which we obtained 147 kidney length measurements from our database. Mean gestational age at time of measurement was 29.7 (range, 18.4-36.7) weeks. Compensatory enlargement, defined as renal length >95(th) percentile for gestational age, was demonstrated in 87% of the MCKD cases and 100% of the URA cases (88% of cases overall). We estimated the mean enlargement for an SFK (defined as difference from 50(th) percentile for normal renal length) at 36 weeks' gestation to be 23.1% (9.25 mm), with the mean value being 11.4% (5.04 mm) greater than the 95(th) percentile for a normal ki...Continue Reading

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Citations

Sep 4, 2013·Pediatric Research·Sébastien SammutMartine Lelièvre Pégorier
Sep 10, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hana FlögelováJana Zapletalová
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Aug 15, 2017·Renal Failure·Mariadelina SimeoniGiorgio Fuiano
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Feb 3, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Hidekazu Naganuma, Ryuichi Nishinakamura
Feb 7, 2014·American Journal of Physiology. Renal Physiology·Yugeesh R LankadevaKate M Denton
Jul 17, 2020·Frontiers in Physiology·Zoe McArdleReetu R Singh
Dec 23, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Noa GiladSharon Perlman
Mar 17, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tülin GüngörMehmet Bülbül
Jul 21, 2021·American Journal of Physiology. Renal Physiology·Jennifer R CharltonKevin M Bennett

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