Compensatory Enlargement of Ossabaw Miniature Swine Coronary Arteries in Diffuse Atherosclerosis

IJC Heart & Vasculature
Jenny S ChoyGhassan S Kassab

Abstract

Studies in human and non-human primates have confirmed the compensatory enlargement or positive remodeling (Glagov phenomenon) of coronary vessels in the presence of focal stenosis. To our knowledge, this is the first study to document arterial enlargement in a metabolic syndrome animal model with diffuse coronary artery disease (DCAD) in the absence of severe focal stenosis. Two different groups of Ossabaw miniature pigs were fed a high fat atherogenic diet for 4 months (Group I) and 12 months (Group II), respectively. Group I (6 pigs) underwent contrast enhanced computed tomographic angiography (CCTA) and intravascular ultrasound (IVUS) at baseline and after 4 months of high fat diet, whereas Group II (7 pigs) underwent only IVUS at 12 months of high fat diet. IVUS measurements of the left anterior descending (LAD), left circumflex (LCX) and right coronary (RCA) arteries in Group I showed an average increase in their lumen cross-sectional areas (CSA) of 25.8%, 11.4%, and 43.4%, respectively, as compared to baseline. The lumen CSA values of LAD in Group II were found to be between the baseline and 4 months values in Group I. IVUS and CCTA measurements showed a similar trend and positive correlation. Fractional flow reserve (FF...Continue Reading

References

Sep 1, 1989·Cardiovascular Research·A M MelkumyantsV M Khayutin
Mar 1, 1987·Journal of Vascular Surgery·C K ZarinsS Glagov
May 28, 1987·The New England Journal of Medicine·S GlagovG J Kolettis
Jul 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M L ArmstrongD J Piegors
Sep 1, 1981·Pharmacological Research Communications·M Amico-RoxasA Bianchi
Mar 8, 1980·British Medical Journal·G D LoweJ C Barbenel
Mar 15, 1993·The American Journal of Cardiology·J B HermillerC J Davidson
Jan 1, 1995·Acta neurochirurgica·S Rossitti, P Svendsen
Dec 11, 1999·JAMA : the Journal of the American Medical Association·A M MalekS Izumo
Feb 28, 2002·Circulation·Amanda M VarnavaMichael J Davies
Aug 21, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ahmet U CoskunPeter H Stone
Jul 13, 2005·European Journal of Pediatrics·Weihua ZhuHenning Neubauer
Nov 22, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Jenny Susana ChoyGhassan S Kassab
May 19, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Aloke V FinnRenu Virmani
Jan 30, 2008·Annals of Biomedical Engineering·Thomas WischgollGhassan S Kassab
Mar 8, 2008·Journal of Applied Physiology·Jenny Susana Choy, Ghassan S Kassab
May 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lydia LeeNaga Chalasani
Jun 13, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Han-Wei WangJi-Xin Cheng
Jun 11, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Rolf P KreutzMichael Sturek
Nov 30, 2011·The International Journal of Cardiovascular Imaging·Sarah RinehartSzilard Voros

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Citations

Feb 16, 2019·Scientific Reports·Monica C LinMichel M Maharbiz
Mar 3, 2020·Annual Review of Biomedical Engineering·Michael SturekFrank W Sellke

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