Compensatory Hippocampal Connectivity in Young Adults With Early-Stage Type 2 Diabetes

The Journal of Clinical Endocrinology and Metabolism
Fang FangYu-Fan Wang

Abstract

Middle-aged to elderly patients with type 2 diabetes mellitus (T2DM) exhibit reduced functional connectivity and brain atrophy underlying cognitive decrements; however, little is known about brain abnormalities in young patients. To detect brain anatomical and functional changes in young patients with T2DM during the early disease stage. Case-control study. Tertiary referral hospital. Thirty-five young patients with T2DM (<40 years of age) with no detectable microangiopathy and 32 nondiabetic control subjects. None. Subjects underwent neuropsychological assessments and structural and resting-state functional MRI. Both voxel-based morphometry and resting-state functional connectivity analyses were performed. No significant differences in brain volume were observed between the patients with T2DM and the controls after controlling for age, sex, education, and body mass index. Compared with the controls, the patients showed greater connectivity of the left hippocampus with the left inferior frontal gyrus and the left inferior parietal lobule. Moreover, the enhanced functional connectivity of left hippocampus with the left inferior frontal gyrus significantly correlated with disease severity (urinary albumin-to-creatinine ratio) (r ...Continue Reading

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Citations

Mar 1, 2019·The Journal of Clinical Endocrinology and Metabolism·Fang FangYu-Fan Wang
Jun 25, 2021·Frontiers in Neuroscience·Kevin K K YuAlex Kwok-Kuen Cheung
Oct 24, 2021·The European Journal of Neuroscience·Suji LeeSujung Yoon

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