Compensatory motor network connectivity is associated with motor sequence learning after subcortical stroke

Behavioural Brain Research
Katie P WaddenLara A Boyd

Abstract

Following stroke, functional networks reorganize and the brain demonstrates widespread alterations in cortical activity. Implicit motor learning is preserved after stroke. However the manner in which brain reorganization occurs, and how it supports behavior within the damaged brain remains unclear. In this functional magnetic resonance imaging (fMRI) study, we evaluated whole brain patterns of functional connectivity during the performance of an implicit tracking task at baseline and retention, following 5 days of practice. Following motor practice, a significant difference in connectivity within a motor network, consisting of bihemispheric activation of the sensory and motor cortices, parietal lobules, cerebellar and occipital lobules, was observed at retention. Healthy subjects demonstrated greater activity within this motor network during sequence learning compared to random practice. The stroke group did not show the same level of functional network integration, presumably due to the heterogeneity of functional reorganization following stroke. In a secondary analysis, a binary mask of the functional network activated from the aforementioned whole brain analyses was created to assess within-network connectivity, decreasing t...Continue Reading

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Citations

Apr 14, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Julie BernhardtNick Ward
Aug 12, 2016·Neurorehabilitation and Neural Repair·Katie P WaddenLara A Boyd
Feb 16, 2019·Reviews in the Neurosciences·Adela Desowska, Duncan L Turner
Sep 15, 2019·Human Brain Mapping·Christiane DahmsCarsten M Klingner
Mar 14, 2020·Human Brain Mapping·Cristián ModroñoJosé L González-Mora
Feb 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao HanYihuai Zou
Jun 14, 2019·Frontiers in Human Neuroscience·Kimberly MillaNancy Getchell
Apr 26, 2016·Translational Stroke Research·Jessica M Cassidy, Steven C Cramer
Aug 15, 2017·Neurorehabilitation and Neural Repair·Julie BernhardtNick Ward
Oct 19, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Codruta BirleDafin F Muresanu
Apr 8, 2021·Neurorehabilitation and Neural Repair·Sarah N KraeutnerLara A Boyd

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