Compensatory nearly neutral mutations: selection without adaptation

Journal of Theoretical Biology
D L Hartl, C H Taubes

Abstract

One implication of Kacser's analysis of complex metabolic systems is that mutations with small effects exist as a consequence of the typically small flux control coefficient relating enzyme activity to the rate of a metabolic process. Although a slightly detrimental mutation is somewhat less likely to become fixed by chance than a slightly favorable mutation, mutations that are slightly detrimental might be expected to be more numerous than favorable mutations owing to the previous incorporation of favorable mutations by a long history of natural selection. The result is that, as Ohta has pointed out, a significant fraction of mutations that are fixed in evolution are slightly detrimental. In the long run, the fixation of detrimental mutations in a gene increases the opportunity for the occurrence of a compensatory favorable mutation, either in the same gene or in an interacting gene. On a suitably long timescale, therefore, every gene incorporates favorable mutations that compensate for detrimental mutations previously fixed. This form of evolution is driven primarily by natural selection, but it results in no change or permanent improvement in enzymatic function.

Citations

Feb 18, 2005·Nature Reviews. Genetics·H Allen Orr
Nov 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michael Lynch
May 24, 2011·Genome Biology and Evolution·Mary M Rorick, Günter P Wagner
Mar 28, 2009·Proceedings. Biological Sciences·Brad H DavisMichael C Whitlock
Jul 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Abhirami RatnakumarMatthew T Webster
Dec 7, 2000·Evolution; International Journal of Organic Evolution·A Poon, S P Otto
Sep 11, 2002·Evolution; International Journal of Organic Evolution·H Allen Orr
Nov 9, 2011·BMC Evolutionary Biology·Hervé Le NagardOlivier Tenaillon
Aug 13, 2008·BMC Evolutionary Biology·Robert C McBridePaul E Turner
Dec 24, 2010·The Journal of Experimental Biology·Walter F Eanes
Oct 27, 2005·PLoS Biology·Rebecca MontvillePaul E Turner
Mar 4, 2014·PLoS Computational Biology·Katherine C H AmrineDavid H Ardell
Nov 21, 2007·PLoS Genetics·Pierrick LabbéThomas Lenormand
Dec 8, 2004·Genetics·Homayoun C Bagheri, Günter P Wagner
Apr 6, 2007·Genetics·K Ryo Takahasi
Jul 29, 2008·Genetics·Jacob A Moorad, Daniel E L Promislow
Jan 5, 2011·Genetics·Pablo Razeto-BarryRodrigo A Vásquez
Jun 5, 2012·Genetics·Sidhartha GoyalMichael M Desai
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Takeshi ItohMasatoshi Nei
Jun 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Guy Sella, Aaron E Hirsh
Jul 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Rosario GilAndrés Moya
Nov 1, 2014·Annual Review of Ecology, Evolution, and Systematics·O Tenaillon
Oct 15, 2005·The American Naturalist·D Waxman, J J Welch
Sep 10, 2014·The Quarterly Review of Biology·David M McCandlish, Arlin Stoltzfus
Oct 6, 2015·Annual Review of Genetics·Detlef Weigel, Magnus Nordborg
Sep 25, 2003·Evolution; International Journal of Organic Evolution·John J Welch, David Waxman
Apr 28, 2016·BioMed Research International·Sandip Chakraborty, David Alvarez-Ponce
Jan 25, 2018·Annals of the New York Academy of Sciences·Tim Connallon, Matthew D Hall
Sep 15, 2005·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Homayoun C Bagheri
Jun 15, 1999·Biulleten' eksperimental'noĭ biologii i meditsiny·V L ChesnokovaE V Sokurenko
Oct 15, 2009·Journal of Evolutionary Biology·J A Moorad, D W Hall
Nov 20, 2010·American Journal of Physical Anthropology·Eugene E Harris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.