PMID: 18411516Apr 17, 2008Paper

Compensatory reaction during degeneration of arcuate nucleus dopaminergic neurons in rats

Zhurnal evoliutsionnoĭ biokhimii i fiziologii
G Z ZiiazetdinovaM V Ugriumov

Abstract

The study has been carried out to verify the authors' hypothesis that degeneration of dopaminergic (DA-ergic) neurons of the hypothalamic tuberoinfundibular system and concomitant development of hyperprolactinemia are accompanied by involvement of compensatory synthesis of dopamine (DA) by non-dopaminergic neurons expressing single complementary enzymes of synthesis of this neurotransmitter. Degeneration of DA-ergic neurons was produced by a stereotaxic injection into the brain lateral ventricles of 6-hydroxydopamine (6-OHDA) - a specific neurotoxin of DA-ergic neurons. 14 and 45 days after the toxin administration there were determined concentration of prolactine in peripheral blood by methods of immunoenzyme and radioimmunological analyses as well as the DA amount in the arcuate nucleus by the method of highly efficient liquid chromatography with electrochemical detection. In a part of the animals, slices were prepared from the mediobasal hypothalamus (arcuate nucleus and medial eminence) and perfused with Krebs-Ringer medium; then the DA concentration was determined in the slices and in the incubation medium. 14 days after the neurotoxin administration there were revealed an increase of blood prolactine concentration and a d...Continue Reading

References

Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Feb 1, 1970·Journal of Neurochemistry·N J Uretsky, L L Iversen
Jan 1, 1984·Journal of Neural Transmission·T A Reader, P Gauthier
Mar 14, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Susanne NikolausHans-Wilhelm Müller-Gärtner

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Citations

Apr 11, 2009·Journal de la Société de biologie·Mikhail V Ugrumov

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