Compensatory renal hypertrophy and the handling of an acute nephrotoxicant in a model of aging

Experimental Gerontology
Cláudia S OliveiraChristy C Bridges

Abstract

Aging often results in progressive losses of functioning nephrons, which can lead to a significant reduction in overall renal function. Because of age-related pathological changes, the remaining functional nephrons within aged kidneys may be unable to fully counteract physiological and/or toxicological challenges. We hypothesized that when the total functional renal mass of aged rats is reduced by 50%, the nephrons within the remnant kidney do not fully undergo the functional and physiological changes that are necessary to maintain normal fluid and solute homeostasis. We also tested the hypothesis that the disposition and handling of a nephrotoxicant are altered significantly in aged kidneys following an acute, 50% reduction in functional renal mass. To test these hypotheses, we examined molecular indices of renal cellular hypertrophy and the disposition of inorganic mercury (Hg(2+)), a model nephrotoxicant, in young control, young uninephrectomized (NPX), aged control and aged NPX Wistar rats. We found that the process of aging reduces the ability of the remnant kidney to undergo compensatory renal growth. In addition, we found that an additional reduction in renal mass in aged animals alters the disposition of Hg(2+) and pote...Continue Reading

References

Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R K Zalups, G L Diamond
Jan 1, 1987·Bulletin of Environmental Contamination and Toxicology·R K Zalups, G L Diamond
Apr 1, 1980·Mechanisms of Ageing and Development·R KrokerM S Anwer
Feb 15, 1994·Archives of Biochemistry and Biophysics·L H Lash, R K Zalups
Dec 10, 1999·Molecular Biology of the Cell·R PfeifferF Verrey
Jul 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Allan FlyvbjergRuth Rasch
Oct 7, 2004·The American Journal of Pathology·Christy C Bridges, Rudolfs K Zalups
Sep 16, 2006·Critical Reviews in Toxicology·Thomas W Clarkson, Laszlo Magos
May 31, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christy C BridgesRudolfs K Zalups
Jun 29, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Christy C Bridges, Rudolfs K Zalups
Nov 17, 2010·Biochemistry. Biokhimii︠a︡·E E Dubinina, V A Dadali
Oct 17, 2012·Hypertension·Isabel Rodríguez-GómezFélix Vargas
Feb 20, 2014·Experimental Gerontology·Christy C BridgesRudolfs K Zalups
Aug 26, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rudolfs K ZalupsChristy C Bridges

❮ Previous
Next ❯

Citations

Jul 17, 2016·Archives of Toxicology·Christy C Bridges, Rudolfs K Zalups
Mar 3, 2018·Journal of Toxicology and Environmental Health. Part a·Sarah E OrrChristy C Bridges
Mar 25, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Christy C Bridges, Rudolfs K Zalups
May 31, 2018·Journal of Toxicology and Environmental Health. Part a·Lucélia Moraes-SilvaMaria Ester Pereira
Dec 7, 2018·Journal of Toxicology and Environmental Health. Part a·Sarah E OrrChristy C Bridges

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.