Apr 27, 2020

RIT1: A Novel Biomarker in Glioblastoma

BioRxiv : the Preprint Server for Biology
Athar Khalil, G. Nemer

Abstract

Background: Glioblastoma is the most common type of malignant brain tumor and the most feared cancer among adults. Based on in vitro and in vivo models, it was recently postulated that the deregulated expression in glioblastomas of key genes known to be involved in early neurogenesis could be the instigator of brain tumorigenesis. Objectives: Our objective is to show that the expression of such genes like RIT1 (Ras Like Without CAAX 1) which encodes an unusual orphan GTPase protein could be useful in early diagnosis of glioblastoma. Methods: We surveyed RIT1 expression and potential role in glioblastoma in-silico using various publicly available datasets. Results: We showed a significant and progressive upregulation of RIT1 expression in various glioblastoma datasets. RIT1 expression ranked among the top upregulated genes (4-7%) and correlated with poor survival outcomes (HR =5.7, 95% CI). Genetic and epigenetic analysis did not reveal significant aberrations that could underlie this deregulated expression, but its transcriptional activity could be significantly controlled by STAT3, one of the main players in the onset of glioblastoma. Conclusions: This is the first report that identifies RIT1 as an oncogene in glioblastoma pav...Continue Reading

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Mentioned in this Paper

Exertion
Rana fisheri
Evaluation
Zebrafish
Genus Reithrodontomys
Sander vitreus
Non-Randomized Controlled Trials as Topic
Population Group
Vitreous Humor
Lophius piscatorius

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