PMID: 16629160Apr 25, 2006Paper

Compensatory responses induced by oxidative stress in Alzheimer disease

Biological Research
Paula I MoreiraG Perry

Abstract

Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-beta deposition and hyperphosphorylated tau function as compensatory responses and downstream adaptations to ensure that neuronal cells do not succumb to oxidative damage. These findings suggest that Alzheimer disease is associated with a novel balance in oxidant homeostasis.

Citations

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Jun 16, 2007·BMC Structural Biology·Weiwei HeCong-Zhao Zhou
Nov 9, 2016·The Journal of Nutritional Biochemistry·Mounir BelkouchNathalie Bernoud-Hubac
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Jul 14, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Aleksandra Maruszak, Cezary Żekanowski
Apr 8, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Kimberly FerreroDianne Langford
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Jan 3, 2020·Current Medicinal Chemistry·Ting YangHailin Cong

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