PMID: 40135Nov 8, 1979

Competence for genetic transformation in pneumococcus depends on synthesis of a small set of proteins

Nature
D A Morrison, M F Baker

Abstract

In bacterial genetic transformation the uptake of DNA and its integration into the resident chromosome is dependent on a special cellular state, termed competence. In those species where appearance of competence has been studied, specific (but often poorly defined) growth conditions lead to a simultaneous development of competence in a substantial fraction of the cells in a culture. In Bacillus subtilis, and in Haemophilus species, competence appears in the stationary phase of growth or in certain other growth-limiting conditions. Streptococcus pneumoniae (pneumococcus) is perhaps unusual in that virtually all cells of a culture become competent, for a short period at a specific cell density during logarithmic growth, without perturbing the growth rate. The synchronous appearance of competence in pneumococcal cultures results from an autocatalytic effect of a small protein released by the cells that induces competence. The response to competence factor has been shown to require protein synthesis. We report here additional information on the nature of competence in pneumococcus: pulse-labelling studies show that for the brief period of competence protein synthesis is restricted to a few specific polypeptides.

References

Nov 1, 1978·Journal of Bacteriology·D A Morrison
Aug 15, 1975·European Journal of Biochemistry·R A Laskey, A D Mills
Jan 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·A TOMASZ, J L Mosser
Aug 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·G T Javor, A TOMASZ
Mar 1, 1969·Journal of Bacteriology·R D Porter, W R Guild
Nov 1, 1971·Journal of Bacteriology·D C DooleyE W NESTER
Oct 1, 1965·Journal of Bacteriology·H T Spencer, R M HERRIOTT
Jul 1, 1961·The Journal of General Physiology·S H GOODGAL, R M HERRIOTT
Mar 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·A TOMASZ, R D HOTCHKISS

Citations

Oct 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R F Rosenzweig, J Adams
Jan 1, 1982·Molecular & General Genetics : MGG·J L Raina, F L Macrina
Jan 1, 1994·Progress in Biophysics and Molecular Biology·A G Sabelnikov
Jun 12, 2002·Current Opinion in Microbiology·John I GlassGregory T Robertson
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J L Raina, A W Ravin
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P E LoveR E Yasbin
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·L S HåvarsteinD A Morrison
Jul 1, 1995·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·A Tomasz, R Munoz
Jul 1, 1996·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·D ZähnerR Hakenbeck
Apr 1, 1997·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·D A Morrison
Jul 11, 1992·Nucleic Acids Research·Bernard MartinR Hakenbeck
Jun 1, 1994·Molecular Microbiology·B J PearceH R Masure
Dec 16, 1998·APMIS. Supplementum·L S Håvarstein
Jul 3, 2007·Journal of Bacteriology·Donald A MorrisonJean-Pierre Claverys
Feb 9, 2010·Journal of Bacteriology·Wilmara Salgado-PabónJoseph P Dillard
Feb 24, 2001·Journal of Bacteriology·Y H LiD G Cvitkovitch
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Christopher M Waters, Bonnie L Bassler
Jun 15, 2006·Annual Review of Microbiology·Jean-Pierre ClaverysBernard Martin
Feb 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Richard MalleyDouglas T Golenbock
Feb 7, 2014·Nucleic Acids Research·Marion BoudesSophie Quevillon-Cheruel
Mar 12, 2013·TheScientificWorldJournal·S InagakiM Matsumoto-Nakano
Jan 1, 1986·Critical Reviews in Microbiology·R D Porter
Feb 26, 2009·Oral Microbiology and Immunology·S InagakiT Ooshima
Aug 1, 1991·Nurse Education Today·P Ashworth, P Morrison
Feb 21, 2009·FEMS Microbiology Reviews·Jean-Pierre ClaverysPatrice Polard
Oct 27, 2006·FEMS Microbiology Letters·Huichun TongXiuzhu Dong
Aug 11, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D G Cvitkovitch
Apr 16, 1998·Molecular Microbiology·E A CampbellH R Masure
Jan 1, 1984·The Journal of Membrane Biology·M E Kahn, H O Smith

Related Concepts

Bacterial Proteins
Recombination, Genetic
Streptococcus pneumoniae
Transformation, Bacterial

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