PMID: 2496103May 1, 1989Paper

Competence-specific induction of the Bacillus subtilis RecA protein analog: evidence for dual regulation of a recombination protein

Journal of Bacteriology
C M LovettR E Yasbin

Abstract

The development of competence in Bacillus subtilis is accompanied by the transcriptional activation of DNA damage-inducible (din) operons and other SOS-like responses. We report here that B. subtilis Rec protein (the analog of Escherichia coli RecA), a DNA damage-inducible protein, is substantially induced when cells differentiate to a state of competence. We quantitated the induction of B. subtilis Rec protein and the B. subtilis din-22 operon (representative of all known B. subtilis din operons) during competence development in Rec+ and DNA repair-deficient strains. We present two lines of evidence that Rec protein induction in competent cells is controlled by a competence-specific mechanism that is distinct from the SOS-like regulation that controls Rec induction following DNA damage: (i) Rec protein was significantly induced in rec mutants (recA1 and recE4) that are highly deficient in Rec induction by DNA damage, and (ii) Rec protein induction during competence development was greater than maximum Rec induction by DNA damage. On the other hand, our results suggest that the din-22 operon is induced by the same (SOS-like) mechanism both during competence development and after DNA damage.

References

Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P E Love, R E Yasbin
Sep 1, 1986·Microbiological Reviews·R H Doi, L F Wang
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H L Carter, C P Moran
Jul 1, 1987·Journal of Bacteriology·M AlbanoD Dubnau
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·F A FerrariJ A Hoch
Mar 1, 1988·Journal of Bacteriology·E DubnauI Smith
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P E LoveR E Yasbin
Mar 1, 1968·Journal of Bacteriology·C Hadden, E W Nester
Jan 1, 1971·Molecular & General Genetics : MGG·W J Harris, G C Barr
Jan 1, 1982·Annual Review of Genetics·C M Radding
Dec 1, 1984·Journal of Bacteriology·P E Love, R E Yasbin
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J W LittleD W Mount
Jun 1, 1981·Journal of Bacteriology·D M WilliamsP S Lovett
Sep 1, 1981·Cell·R Losick, J Pero
Jan 1, 1982·Molecular & General Genetics : MGG·J L Raina, F L Macrina
Jan 1, 1981·Annual Review of Biochemistry·H O SmithR A Deich
May 1, 1982·Cell·J W Little, D W Mount
May 1, 1961·Journal of Bacteriology·C Anagnostopoulos, J Spizizen

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Citations

Jul 1, 1992·Molecular Microbiology·R PalmenK J Hellingwerf
Nov 2, 2002·Molecular Microbiology·Elaine O DavisErik C Böttger
Jan 1, 1993·Archives of Microbiology·C P RubinsteinC Sanchez-Rivas
Apr 16, 1998·Molecular Microbiology·E A CampbellH R Masure
Mar 28, 2017·Genes & Genetic Systems·Motohiro AkashiHirofumi Yoshikawa
Jan 1, 1993·Antonie van Leeuwenhoek·B VosmanK J Hellingwerf
Aug 12, 2017·Frontiers in Microbiology·Alejandra L Ibáñez de AldecoaJosé E González-Pastor
Apr 9, 2001·Journal of Bacteriology·S A SciochettiP J Piggot
Feb 15, 2000·Research in Microbiology·E P RochaA Viari
Jan 1, 1995·Journal of Bacteriology·B J PearceH R Masure
May 1, 1992·Journal of Bacteriology·A Raymond-Denise, N Guillen
Sep 1, 1991·Microbiological Reviews·D Dubnau
Oct 1, 1991·Journal of Bacteriology·M F WojciechowskiP E Love
Nov 1, 1991·Journal of Bacteriology·A Raymond-Denise, N Guillen
Sep 1, 1994·Microbiological Reviews·M G Lorenz, W Wackernagel
Feb 26, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Richard E MichodAurora M Nedelcu

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