Competing mortality risks among women aged 50-79 years when diagnosed with invasive breast cancer, Queensland, 1997-2012

The Breast : Official Journal of the European Society of Mastology
Paramita DasguptaPeter D Baade

Abstract

Understanding the burden of competing (non-breast cancer) mortality is important for the growing number of breast cancer survivors. We quantity these patterns, and the impact of two leading non-cancer causes of death, within ten years of breast cancer diagnosis. Population based cancer registry study of 23,809 women aged 50-79 diagnosed with first primary breast cancer in Queensland, Australia, 1997 to 2012 with additional data linkage to identify individual non-cancer mortality causes. Flexible parametric competing-risks models were used to estimate the crude and adjusted probabilities of death. While overall mortality increased with age at diagnosis, this effect was strongest for non-cancer (such as cardiovascular and cerebrovascular disease) mortality. Women diagnosed with advanced breast cancer had a higher crude probability of breast cancer death (23.1% versus 4.5% for localised) but similar probability of competing mortality (11.6% versus 11.3%). Within each category of spread of disease, the probability of breast-cancer deaths remained relatively constant with age, while the probability of competing deaths increased. The 10-year probability of dying from breast cancer was 3.7%, 4.2% and 5.6% among women with localised di...Continue Reading

Citations

Feb 3, 2021·Journal of Geriatric Oncology·Willeke G van der Plas-KrijgsmanNienke A de Glas
May 8, 2020·The Breast : Official Journal of the European Society of Mastology·Sophie FrankPaul Cottu
May 13, 2021·JAMA Surgery·Tyler R ChesneyUNKNOWN Recovery After Surgical Therapy for Older Adults Research–Cancer (RESTORE-Cancer) Group

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