Competing neurobehavioral decision systems theory of cocaine addiction: From mechanisms to therapeutic opportunities

Progress in Brain Research
W K BickelColleen A Hanlon

Abstract

Cocaine dependence is a difficult-to-treat, chronically relapsing disorder. Multiple scientific disciplines provide distinct perspectives on this disorder; however, connections between disciplines are rare. The competing neurobehavioral decision systems (CNDS) theory posits that choice results from the interaction between two decision systems (impulsive and executive) and that regulatory imbalance between systems can induce pathology, including addiction. Using this view, we integrate a diverse set of observations on cocaine dependence, including bias for immediacy, neural activity and structure, developmental time course, behavioral comorbidities, and the relationship between cocaine dependence and socioeconomic status. From the CNDS perspective, we discuss established and emerging behavioral, pharmacological, and neurological treatments and identify possible targets for future treatments. The ability of the CNDS theory to integrate diverse findings highlights its utility for understanding cocaine dependence and supports that dysregulation between the decision systems contributes to addiction.

Citations

Jun 13, 2017·Current Opinion in Behavioral Sciences·Marc L Copersino
Jun 5, 2018·Annals of the New York Academy of Sciences·Peter A HallDylan D Wagner
Dec 27, 2016·Current Treatment Options in Psychiatry·Warren K BickelAmanda J Quisenberry
Oct 9, 2019·Psychological Science in the Public Interest : a Journal of the American Psychological Society·Antoine BecharaJeffrey S Stein
Aug 18, 2018·Learning & Memory·Kyle K PitchersTerry E Robinson
Nov 21, 2020·The American Journal of Drug and Alcohol Abuse·Yong Shen, Heather Burrell Ward
Jan 29, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Eduardo A Garza-VillarrealJorge J Gonzalez-Olvera
Feb 6, 2021·Behavioural Processes·Ricarda K PritschmannRichard Yi
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