Abstract
Cocaine dependence is a difficult-to-treat, chronically relapsing disorder. Multiple scientific disciplines provide distinct perspectives on this disorder; however, connections between disciplines are rare. The competing neurobehavioral decision systems (CNDS) theory posits that choice results from the interaction between two decision systems (impulsive and executive) and that regulatory imbalance between systems can induce pathology, including addiction. Using this view, we integrate a diverse set of observations on cocaine dependence, including bias for immediacy, neural activity and structure, developmental time course, behavioral comorbidities, and the relationship between cocaine dependence and socioeconomic status. From the CNDS perspective, we discuss established and emerging behavioral, pharmacological, and neurological treatments and identify possible targets for future treatments. The ability of the CNDS theory to integrate diverse findings highlights its utility for understanding cocaine dependence and supports that dysregulation between the decision systems contributes to addiction.
Citations
Jun 13, 2017·Current Opinion in Behavioral Sciences·Marc L Copersino
Jun 5, 2018·Annals of the New York Academy of Sciences·Peter A HallDylan D Wagner
Nov 15, 2019·Journal of Addiction Medicine·Mauro PettorrusoGeorge F Koob
Dec 27, 2016·Current Treatment Options in Psychiatry·Warren K BickelAmanda J Quisenberry
Jul 17, 2018·Current Behavioral Neuroscience Reports·Colleen A HanlonMark S George
Oct 9, 2019·Psychological Science in the Public Interest : a Journal of the American Psychological Society·Antoine BecharaJeffrey S Stein
Aug 18, 2018·Learning & Memory·Kyle K PitchersTerry E Robinson
Mar 31, 2019·Addiction·William MellickJames J Prisciandaro
Nov 21, 2020·The American Journal of Drug and Alcohol Abuse·Yong Shen, Heather Burrell Ward
Jan 29, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Eduardo A Garza-VillarrealJorge J Gonzalez-Olvera
Feb 6, 2021·Behavioural Processes·Ricarda K PritschmannRichard Yi
Mar 23, 2019·Journal of Substance Abuse Treatment·Sarah E ForsterSteven D Forman
Jul 16, 2017·Pharmacology, Biochemistry, and Behavior·Serge H Ahmed
Jun 24, 2021·Reviews in Endocrine & Metabolic Disorders·Nicholas ParsonsLeonie Duehlmeyer
Jun 14, 2021·Drug and Alcohol Dependence·Sarah E SniderWarren K Bickel
Jul 20, 2021·Contemporary Clinical Trials Communications·Sarah E ForsterStuart R Steinhauer
Aug 7, 2021·Neuroscience and Biobehavioral Reviews·Warren K BickelLeonard H Epstein
Sep 17, 2021·Frontiers in Psychiatry·Aldo Alberto Conti, Alexander Mario Baldacchino
Nov 13, 2021·PloS One·Jeffrey S Stein, Gregory J Madden