Competing risk analyses of overall survival and cancer-specific survival in patients with combined hepatocellular cholangiocarcinoma after surgery

BMC Cancer
Chaobin HeXiaojun Lin

Abstract

Our objective was to identify risk factors affecting overall survival (OS) and cancer-specific survival (CSS) and build nomograms to predict survival based on a large population-based cohort. Two hundred and thirty patients diagnosed with CHCC between 2004 and 2015 were retrospectively extracted from the Surveillance, Epidemiology, and End Results (SEER) database as a training cohort. In addition, Ninety-nine patients diagnosed with CHCC between 2000 and 2017 were retrospectively extracted from Sun Yat-Sen University Cancer Center (SYSUCC) as an external validation. Nomograms for predicting probability of OS and CSS were established. Performance of the nomograms was measured by concordance index (C-index) and the area under receiver operating characteristic (ROC) curve (AUC). In training cohort, the 1-, 2 and 3-year OS were 67.7, 46.8 and 37.9%, and the 1-, 2 and 3-year CSS were 73.1, 52.0 and 43.0%, respectively. The established nomograms were well calibrated in both training and validation cohort, with concordance indexes (C-index) of 0.652 and 0.659, respectively for OS prediction; 0.706 and 0.763, respectively for CSS prediction. Nomograms also displayed better discriminatory compared with 8th edition tumor-node-metastasis ...Continue Reading

References

Apr 25, 2006·Journal of Clinical Epidemiology·Colleen M NorrisUNKNOWN APPROACH Investigators
Dec 2, 2006·Journal of Hepato-biliary-pancreatic Surgery·Songyos ChantajitrNinatthanan Phromsopha
Feb 21, 2008·International Journal of Clinical Practice·W T Kassahun, J Hauss
Oct 20, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jean-Luc Szpakowski, Lue-Yen Tucker
Aug 27, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marlies NoordzijKitty J Jager
Dec 29, 2013·European Journal of Gastroenterology & Hepatology·Kai-jian ChuXiao-ping Yao
Jun 10, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S H KimK S Kim
Jan 19, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Tobias S SchiergensWolfgang E Thasler
Aug 23, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·John R BergquistRory L Smoot
Feb 21, 2018·Journal of Cancer Research and Clinical Oncology·Dan LiYing Yuan
Apr 19, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Chaobin HeShengping Li
Jul 20, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Junichi ShindohMasaji Hashimoto

❮ Previous
Next ❯

Citations

May 1, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Feng ZhangXin Yin
Aug 6, 2020·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Dimitrios SchizasEvangelos Felekouras

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS
SYSUCC
R

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.