Competition between congenic Escherichia coli K-12 strains in vivo.

Infection and Immunity
A OnderdonkS B Levy

Abstract

The ability of Escherichia coli to colonize the large bowels of animals is related to many factors inherent to the intestinal environment and the bacterium. The use of germfree mice eliminates the competition between E. coli and the other microflora and allows most E. coli strains to colonize. We found that E. coli K-12 strains differing in chromosomal antibiotic resistance could monoassociate in germfree mice in large numbers. However, when two or more strains were in competition with each other, we detected quantitative differences in the abilities of the strains to colonize. The order of colonizing ability was as follows: nalidixic acid resistance greater than streptomycin resistance greater than rifampin resistance. We also found that a nalidixic acid-resistant strain bearing plasmid pBR322 colonized less efficiently and at lower levels when in competition with the nalidixic acid-resistant strain. Studies of the membrane proteins of the various strains indicated that changes in membrane proteins occurred concomitantly with altered resistance to antimicrobial agents. These results suggest that chromosomally linked alterations in antimicrobial sensitivity may also reflect changes in membrane proteins and a decreased ability t...Continue Reading

References

Dec 1, 1974·The American Journal of Clinical Nutrition·S M FinegoldV L Sutter
Jun 1, 1970·The Keio Journal of Medicine·S SasakiR Maeda
Apr 1, 1980·Infection and Immunity·A B OnderdonkJ G Bartlett
Jul 1, 1965·The Journal of Experimental Medicine·R W SCHAEDLERR COSTELLO

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Citations

Jul 1, 1990·Archiv für Tierernährung·M VanbelleM Focant
Jul 8, 1982·The New England Journal of Medicine·P A Mackowiak
Jul 16, 2002·Journal of Food Protection·Genevieve A Barkocy-GallagherMohammad Koohmaraie
Dec 6, 2002·Journal of Medical Microbiology·Adrian L CooksonMartin J Woodward
Jan 1, 2013·Pathogens·David LebeauxChristophe Beloin
May 16, 2017·Parasitology·Benjamin J Z QuigleyAngus Buckling
Apr 1, 1989·Antimicrobial Agents and Chemotherapy·D E CorpetF Corpet
Dec 1, 1992·Applied and Environmental Microbiology·R E MurrayM S Smith
Oct 1, 1988·Applied and Environmental Microbiology·G CompeauS B Levy

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