Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche.

Immunity
Toshiro HiraiDaniel H Kaplan

Abstract

Following antigen-driven expansion in lymph node, transforming growth factor-β (TGFβ) is required for differentiation of skin-recruited CD8+ T cell effectors into epidermal resident memory T (Trm) cells and their epidermal persistence. We found that the source of TGFβ -supporting Trm cells was autocrine. In addition, antigen-specific Trm cells that encountered cognate antigen in the skin, and bystander Trm cells that did not, both displayed long-term persistence in the epidermis under steady-state conditions. However, when the active-TGFβ was limited or when new T cell clones were recruited into the epidermis, antigen-specific Trm cells were more efficiently retained than bystander Trm cells. Genetically enforced TGFβR signaling allowed bystander Trm cells to persist in the epidermis as efficiently as antigen-specific Trm cells in both contexts. Thus, competition between T cells for active TGFβ represents an unappreciated selective pressure that promotes the accumulation and persistence of antigen-specific Trm cells in the epidermal niche.

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Citations

Mar 20, 2021·Cell·Stuart P WeisbergDonna L Farber
Apr 11, 2021·European Journal of Immunology·Klaas P J M van GisbergenChristian Münz
May 1, 2021·Cells·Zhijuan QiuBrian S Sheridan
May 29, 2021·Nature Reviews. Disease Primers·Pamela L ScheinmanAri M Goldminz
Jun 12, 2021·Frontiers in Immunology·Salomé LeibundGut-Landmann
Jun 23, 2021·Current Opinion in Allergy and Clinical Immunology·Marine-Alexia LefevreAudrey Nosbaum
Aug 28, 2021·Cells·Juliana Barreto de AlbuquerqueBilgi Gungor

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