Competition versus Cooperation in Catalytic Hydrogelators for anti-Selective Mannich Reaction

Chemistry : a European Journal
Nishant Singh, Beatriu Escuder

Abstract

Chemical systems find similarities in different sociological and biological processes, in which the entities compete or cooperate for a favorable outcome. The structural and functional adaptations leading to emergent properties, especially in catalysis, are based on factors such as abundance of substrates, stability of the transition state, and structural/functional attributes of catalysts. Proline and acid groups appended to catalytic fibers of two self-sorting hydrogelators compete for the Mannich reaction between aniline, benzaldehyde, and cyclohexanone to give low overall selectivity (anti/syn 77:23). In a sol-gel system of the same molecules, on the other hand, the soluble acid appended molecules tend to cooperate with the fibers of proline-appended catalyst to give improved selectivity (anti/syn 95:5). The available options for the catalytic molecules are to carry out the reaction independently or in cooperation. However, these options are chosen based on the efficiency, selectivity, and mobility of catalysts as a result of their abilities to self-assemble.

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Aug 18, 2016·Chemistry : a European Journal·Nishant SinghBeatriu Escuder
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Aug 1, 2016·Chemical Science·Nishant SinghBeatriu Escuder

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Citations

Mar 30, 2018·Chemical Society Reviews·O ZozuliaI V Korendovych
Aug 10, 2018·Chemistry : a European Journal·W Mathis Rink, Franziska Thomas
Jun 21, 2019·Chemical Communications : Chem Comm·Anna Serra-PontCiril Jimeno
Apr 13, 2021·Biomacromolecules·Ian W Hamley
Sep 2, 2021·Chemistry : a European Journal·Souvik MisraJayanta Nanda
Dec 22, 2021·Journal of the American Chemical Society·Nishant SinghThomas M Hermans

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