Competitive elimination of foreign motor innervation on autonomic neurones in the frog heart

The Journal of Physiology
W Proctor, S D Roper

Abstract

1. Somatic motoneurones are capable of forming functional synapses when redirected to vagotomized autonomic neurones in the frog heart. We tested if regenerating vagus nerves could reinnervate ganglion cells in the presence of foreign hypoglossal innervation and, furthermore, whether hypoglossal innervation persisted when vagal axons regenerated to the heart. 2. Simulating the redirected hypoglossus nerve produced a parasympathetic-like cardiac inhibition in the absence of vagal regeneration. However, when the vagus nerve was allowed to regenerate to the heart, vagal cardio-inhibition was restored and hypoglossal inhibition disappeared. 3. Intracellular recordings showed that 71% of the cardiac ganglion cells were innervated by hypoglossal axons before vagal regeneration, but that this value fell to less than 9% over a period of 40 weeks during vagal regeneration. 4. If the vagus nerve was prevented from regenerating to the heart, hypoglossal innervation did not decline, indicating that elimination of the foreign motor innervation was dependent upon vagal reinnervation. 5. Although hypoglossal terminals formed synapses only on the axons of parasympathetic ganglion cells, regenerating vagal fibres re-established synaptic contact...Continue Reading

Citations

Feb 1, 1984·Brain Research·A E SchaffnerM C Fishman
Jan 19, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Lloyd M BuckAlexandra K Papadopoulou
Mar 1, 1995·Chest·W MitznerR H Brown
Feb 14, 2012·Respiratory Physiology & Neurobiology·Yang NaSeung-Kyu Chung
Apr 17, 2016·Immunology and Allergy Clinics of North America·Fuad M Baroody
Sep 9, 2008·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Nanci Lara Oliveira De FelippeCarla A Evans
Jun 21, 2008·Respiratory Physiology & Neurobiology·David EladTilman Keck
Oct 15, 2014·Advanced Drug Delivery Reviews·José L TlaxcaRichard L Remmele
May 1, 1988·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·D W Warren
Jun 19, 1998·Toxicology and Applied Pharmacology·G M KeplerJ S Kimbell
Feb 28, 2004·Brain Research·Laurence JacquotGérard Brand
Oct 18, 2015·Neuroimaging Clinics of North America·Varsha M Joshi, Rima Sansi
Dec 1, 1983·The Journal of Comparative Neurology·B TaylorS D Roper
Apr 9, 2016·Perspectives on Speech Science and Orofacial Disorders·David J Zajac
Oct 23, 1998·Journal of Drug Targeting·S MathisonU B Kompella
Sep 4, 2018·Expert Opinion on Drug Delivery·Wisam Al BakriZhen Yang
Jan 9, 2019·Inhalation Toxicology·Nguyen Lu PhuongKazuhide Ito
Sep 4, 2015·Physiological Reviews·Jonathan H Widdicombe, Jeffrey J Wine
May 17, 1995·Journal of the Autonomic Nervous System·D Eugène, J Taxi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.