PMID: 32539Dec 1, 1978Paper

Competitive inhibition of benzodiazepine binding by fractions from porcine brain

Proceedings of the National Academy of Sciences of the United States of America
G D ColelloK Folkers

Abstract

Fractions of porcine cerebral cortex extract separated by molecular weight on a Sephadex G-75 column were tested for their activities and potencies to inhibit [3H]benzodiazepine binding to rat brain homogenates. The fractions spanned molecular weights from 500 to 100,000. A potent inhibitor (benzodiazepine-competitive factor I, BCF-I) was discovered in the fraction containing substances with molecular weights from 40,000 to 70,000. Equilibrium binding studies indicated that BCF-I was a competitive inhibitor, making it a candidate as a benzodiazepine endogenous factor or profactor. BCF-I was heat stable, but trypsin digestion destroyed its activity. Another inhibitory fraction (BCF-II) was 1/5th as active as BCF-I and contained substances with molecular weights from 1000 to 2000.

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C Braestrup, R F Squires
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Mar 15, 1978·European Journal of Pharmacology·R S Chang, S H Snyder
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M RubinsteinS Udenfriend
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Sep 15, 1973·Journal of Molecular Biology·F W Studier

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Citations

Nov 1, 1991·Neurochemical Research·H KawasakiM Fukahori
Aug 20, 1979·Life Sciences·M NielsenC Braestrup
Jun 1, 1981·Pharmacology, Biochemistry, and Behavior·L G DavisD Reker
May 1, 1984·Peptides·J DeckertH Przuntek
Jan 1, 1983·Neurochemistry International·M Hamon, P Soubrié
Jan 1, 1980·Progress in Neurobiology·F A Henn, S W Henn
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H B BosmannK Averill
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C BraestrupC E Olsen
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A GuidottiE Costa
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L Sangameswaran, A L de Blas
Jan 15, 1980·Biochemical and Biophysical Research Communications·L G Davis, R K Cohen
Jan 1, 1981·Medicinal Research Reviews·P Skolnick, S M Paul
Jan 1, 1981·Journal of Neurochemistry·T H Chiu, H C Rosenberg
Jul 1, 1984·Medicinal Research Reviews·M Simonyi
Mar 1, 1980·The Journal of Pharmacy and Pharmacology·L G Davis, R K Cohen
Jul 1, 1981·International Journal of Peptide and Protein Research·A KenesseyL Gráf
Jul 2, 1982·Science·A S Levine, J E Morley
Jan 18, 1980·Science·J F TallmanD W Gallager
Mar 1, 2011·European Journal of Medicinal Chemistry·Silke HackKlaus T Wanner

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