Competitive NMDA receptor antagonist, CGP 40116, substitutes for the discriminative stimulus effects of ethanol

European Journal of Pharmacology
P BienkowskiW Kostowski

Abstract

A drug discrimination procedure was used to compare the ability of competitive (CGP 37849, D,L-(E)-2-amino-4-methyl-5-phosphono-3-pentanoate; CGP 40116, D-(E)-2-amino-4-methyl-5-phosphono-3-pentanoate) and non-competitive (dizocilpine) NMDA receptor antagonists to substitute for ethanol in rats trained to discriminate between a 1.0 g/kg dose of ethanol (i.p.) and saline. Dizocilpine (0.1-0.3 mg/kg) substituted partially for ethanol at doses that markedly reduced the rate of responding. CGP 37849 (1.25-5.0 mg/kg) substituted partially for ethanol and suppressed the response rate. CGP 40116 (0.5-2.5 mg/kg), and active D-stereoisomer of CGP 37849, completely substituted (88%) for ethanol, and caused only moderate suppression of the response rate.

References

Jun 1, 1992·Alcoholism, Clinical and Experimental Research·W DanyszW Kostowski
Mar 31, 1989·Science·D M LovingerF F Weight
Feb 1, 1993·Alcoholism, Clinical and Experimental Research·E SannaG Biggio

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Citations

Jul 30, 1997·European Journal of Pharmacology·J Kotlinska, S Liljequist
Oct 1, 1998·European Journal of Pharmacology·J PiaseckiP Bienkowski
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·P BienkowskiW Kostowski
Jun 4, 1998·Pharmacology, Biochemistry, and Behavior·P Bienkowski, W Kostowski
Apr 20, 1999·Pharmacology, Biochemistry, and Behavior·E KorosP Bienkowski
Jun 10, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P BienkowskiW Kostowski
Jun 18, 2002·Alcoholism, Clinical and Experimental Research·Keith L Shelton, Kathleen A Grant
Mar 15, 2008·European Journal of Pharmacology·Alexander KuzminSture Liljequist

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