Competitive reinnervation of salamander skin by regenerating and intact mechanosensory nerves

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
S A ScottJ Diamond

Abstract

We have investigated in the salamander the possibility that regenerating mechanosensory nerves might prefer the epidermal Merkel cells (their specific targets) that are located within their segmental domain to those within a "foreign" domain. Since regerating nerves cross domain boundaries with no evidence of the marked delay exhibited by intact sprouting nerves, we examined situations in which the regenerating axons of one segmental nerve were effectively in equal competition for denervated skin with those of another segmental nerve. Additionally, we investigated whether there were differences between regenerating axons and intact sprouting axons of the same segmental nerve, in their ability to innervate available skin both inside and outside the parent domain. No preference was detected of any type of nerve, regenerating or intact, for particular skin regions, or for Merkel cells as indicated by the numbers of mechanosensory thresholds of the touch spots that developed in reinnervated skin. Neither was there any indicating of displacement of "foreign" nerves from a particular region by appropriate axons. When regenerating and intact (sprouting) axons invaded denervated skin more or less simultaneously, the former appeared to ...Continue Reading

References

Jun 20, 1975·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B T JohnstonR F Mark
May 1, 1978·Acta Physiologica Scandinavica·W Thompson
Mar 1, 1971·Journal of Ultrastructure Research·A G Lyne, D E Hollis
Mar 27, 1981·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S A ScottJ Diamond
Mar 27, 1981·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·L Macintyre, J Diamond
Dec 1, 1981·British Journal of Urology·P J SmithD Kirk

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Citations

Oct 1, 1984·Journal of Neurocytology·J Zelená
Mar 27, 1981·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·L Macintyre, J Diamond
Apr 22, 1983·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D L Kitson, A Roberts
Mar 29, 1991·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K J Muller, X N Gu

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