Competitive release of drug resistance following drug treatment of mixed Plasmodium chabaudi infections

Malaria Journal
Jacobus C de RoodeAndrew F Read

Abstract

Malaria infections are often genetically diverse, potentially leading to competition between co-infecting strains. Such competition is of key importance in the spread of drug resistance. The effects of drug treatment on within-host competition were studied using the rodent malaria Plasmodium chabaudi. Mice were infected simultaneously with a drug-resistant and a drug-sensitive clone and were then either drug-treated or left untreated. Transmission was assessed by feeding mice to Anopheles stephensi mosquitoes. In the absence of drugs, the sensitive clone competitively suppressed the resistant clone; this resulted in lower asexual parasite densities and also reduced transmission to the mosquito vector. Drug treatment, however, allowed the resistant clone to fill the ecological space emptied by the removal of the sensitive clone, allowing it to transmit as well as it would have done in the absence of competition. These results show that under drug pressure, resistant strains can have two advantages: (1) they survive better than sensitive strains and (2) they can exploit the opportunities presented by the removal of their competitors. When mixed infections are common, such effects could increase the spread of drug resistance.

References

Jan 22, 1997·Proceedings. Biological Sciences·C Dye, B G Williams
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·H A BabikerD Walliker
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·T SmithM Tanner
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·I FelgerH P Beck
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·H P BeckC Menendez
Jul 20, 2000·Parasitology Today·I M Hastings, U D'Alessandro
May 16, 2001·Science·A F Read, L H Taylor
Mar 19, 2003·Proceedings. Biological Sciences·N J White, W Pongtavornpinyo
Feb 6, 2004·Evolution; International Journal of Organic Evolution·H M FergusonA F Read
Aug 6, 2004·Proceedings. Biological Sciences·Jacobus C de RoodeAndrew F Read

❮ Previous
Next ❯

Citations

Aug 23, 2007·Proceedings. Biological Sciences·Andrew R WargoAndrew F Read
Sep 27, 2013·PLoS Pathogens·Silvie HuijbenAndrew F Read
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Andrew F ReadSilvie Huijben
Oct 15, 2005·The American Naturalist·Jacobus C de RoodeAndrew F Read
Apr 5, 2011·The American Naturalist·Laura C PollittSarah E Reece
Jul 29, 2006·The American Naturalist·Lars RabergAndrew F Read
Mar 18, 2016·Proceedings. Biological Sciences·Mary BushmanVenkatachalam Udhayakumar
Sep 25, 2015·Emerging Infectious Diseases·Sri KrishnaNeeru Singh
Jul 3, 2013·FEMS Microbiology Reviews·Manu VanaerschotJean-Claude Dujardin
Jun 22, 2018·PLoS Computational Biology·Sylvie Estrela, Sam P Brown
Aug 26, 2006·Evolution; International Journal of Organic Evolution·Andrew S BellAndrew F Read
Jun 11, 2008·Evolution; International Journal of Organic Evolution·Katrina GrechAndrew F Read
Feb 1, 2009·Evolutionary Applications·Andrew F Read, Silvie Huijben
May 1, 2009·Evolutionary Applications·Mark P ZwartJenny S Cory
Jun 30, 2010·Evolution; International Journal of Organic Evolution·Silvie HuijbenAndrew F Read
Apr 30, 2014·Parasitology·Alyssa M Gleichsner, Dennis J Minchella
Jun 3, 2009·Expert Review of Anti-infective Therapy·Hamza A BabikerGöte Swedberg
May 22, 2010·Tropical Medicine & International Health : TM & IH·Bhavna GuptaAparup Das
Sep 3, 2011·Journal of Evolutionary Biology·S HuijbenA F Read
Apr 15, 2016·Journal of the Royal Society, Interface·Mathieu Legros, Sebastian Bonhoeffer
Feb 25, 2014·Parasitology Research·Rashad Abdul-GhaniAhmed A Azazy
Jan 6, 2015·Evolutionary Applications·Helen K AlexanderSebastian Bonhoeffer
Jul 12, 2019·Evolutionary Applications·Amrita BhattacharyaFarrah Bashey
Aug 22, 2018·PLoS Biology·Mary BushmanJacobus C de Roode
Aug 9, 2018·Evolution, Medicine, and Public Health·Silvie HuijbenAndrew F Read
Jul 26, 2019·Computational and Mathematical Methods in Medicine·Titus Okello OrwaLivingstone Serwadda Luboobi
Dec 17, 2020·Frontiers in Cellular and Infection Microbiology·Brandi K TorrevillasShirley Luckhart
Aug 28, 2021·Evolution, Medicine, and Public Health·Siobhán O'BrienAlex R Hall
Sep 8, 2021·Frontiers in Microbiology·Manja SaebelfeldJ Arjan G M de Visser
Sep 23, 2008·Vaccine·Victoria C BarclayAndrew F Read

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
PCR

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.