PMID: 16536334Mar 16, 2006Paper

Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods

Dermatitis : Contact, Atopic, Occupational, Drug
G Frank GerberickD A Basketter

Abstract

Within the toxicology community, considerable effort is directed toward the development of alternative methods for skin sensitization testing. The availability of high-quality, relevant, and reliable in vivo data regarding skin sensitization is essential for the effective evaluation of alternative methodologies. Ideally, data derived from humans would be the most appropriate source because the test methods are attempting to predict a toxicologic effect in humans. Unfortunately, insufficient human data of the necessary quality are available, so it is necessary to rely on the best available animal data. In recent years, the local lymph node assay (LLNA) has emerged as a practical option for assessing the skin sensitization potential of chemicals. In addition to accurately identifying skin sensitizers, the LLNA can also provide a reliable measure of relative sensitization potency, information that is pivotal to the successful management of human health risks. To provide a database of robust in vivo data to calibrate, evaluate, and eventually validate new approaches for skin sensitization testing. LLNA data derived from previously conducted studies were compiled from the published literature and unpublished sources. We provide a da...Continue Reading

Citations

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