Complement 1q-like-3 protein inhibits insulin secretion from pancreatic β-cells via the cell adhesion G protein-coupled receptor BAI3.

The Journal of Biological Chemistry
Rajesh GuptaSushant Bhatnagar

Abstract

Secreted proteins are important metabolic regulators in both healthy and disease states. Here, we sought to investigate the mechanism by which the secreted protein complement 1q-like-3 (C1ql3) regulates insulin secretion from pancreatic β-cells, a key process affecting whole-body glucose metabolism. We found that C1ql3 predominantly inhibits exendin-4- and cAMP-stimulated insulin secretion from mouse and human islets. However, to a lesser extent, C1ql3 also reduced insulin secretion in response to KCl, the potassium channel blocker tolbutamide, and high glucose. Strikingly, C1ql3 did not affect insulin secretion stimulated by fatty acids, amino acids, or mitochondrial metabolites, either at low or submaximal glucose concentrations. Additionally, C1ql3 inhibited glucose-stimulated cAMP levels, and insulin secretion stimulated by exchange protein directly activated by cAMP-2 and protein kinase A. These results suggest that C1ql3 inhibits insulin secretion primarily by regulating cAMP signaling. The cell adhesion G protein-coupled receptor, brain angiogenesis inhibitor-3 (BAI3), is a C1ql3 receptor and is expressed in β-cells and in mouse and human islets, but its function in β-cells remained unknown. We found that siRNA-mediated ...Continue Reading

References

Oct 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Yoshikazu Miura, Hisao Matsui
Jul 1, 2005·The Journal of Biological Chemistry·Luis R LandaMichael W Roe
Sep 27, 2005·Physiological Reviews·Susumu Seino, Tadao Shibasaki
Feb 20, 2007·Pharmacology & Therapeutics·Máire E Doyle, Josephine M Egan
Jun 5, 2007·Immunobiology·Rohit GhaiUday Kishore
May 8, 2008·PloS One·Joung Woul KimNirupa Chaudhari
Jul 2, 2008·Cell Metabolism·Oleg DyachokAnders Tengholm
Aug 13, 2008·The Journal of General Physiology·Lavoisier S RamosLonny R Levin
Sep 13, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G William WongHarvey F Lodish
Sep 17, 2008·The Review of Diabetic Studies : RDS·Richard E Pratley, Matthew Gilbert
Jan 24, 2009·BMC Medical Genetics·Andrew D Johnson, Christopher J O'Donnell
Feb 24, 2009·The Journal of Biological Chemistry·Sushant BhatnagarF Bradley Hillgartner
Aug 1, 2009·Science·Chang-Liang ZhangSusumu Seino
Jan 8, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jenna L JewellDebbie C Thurmond
Mar 11, 2010·Advances in Experimental Medicine and Biology·Brian FurmanNigel J Pyne
Sep 22, 2010·Therapeutics and Clinical Risk Management·Jonathan PinkneyLakshminarayan Ranganath
Jan 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Marc F BolligerThomas C Südhof
Feb 23, 2011·Chemistry & Biology·Katie J HerbstJin Zhang
Jun 3, 2011·The Journal of Clinical Investigation·Susumu SeinoKohtaro Minami
Jan 21, 2012·Trends in Endocrinology and Metabolism : TEM·Andreas Schäffler, Christa Buechler
Sep 14, 2012·Upsala Journal of Medical Sciences·Anders Tengholm
Jun 25, 2013·Cell Metabolism·Marc PrentkiS R Murthy Madiraju
Aug 22, 2013·Reviews in Endocrine & Metabolic Disorders·Marcus M SeldinG William Wong
Aug 27, 2013·Current Medical Research and Opinion·Stuart A Ross, Jane Ballantine
Sep 18, 2013·Nature Reviews. Endocrinology·Frances M Ashcroft, Patrik Rorsman
Feb 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Noumeira HamoudJean-François Côté
Jun 21, 2014·Experimental & Molecular Medicine·Michelle E KimplePatrick J Casey
Jul 9, 2014·The Journal of Biological Chemistry·Sushant BhatnagarAlan D Attie
Feb 24, 2015·The Biochemical Journal·Guy A RutterAida Martinez-Sanchez

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Citations

Jan 5, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anni TanYanhong Yu
Jul 11, 2020·Expert Opinion on Drug Discovery·Andrey D BondarevHelgi B Schiöth
Aug 1, 2019·Scientific Reports·Alexander Bernd KnierimTorsten Schöneberg
Oct 6, 2020·American Journal of Physiology. Endocrinology and Metabolism·Dylan C SarverG William Wong
Dec 19, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matthew J SticcoDavid C Martinelli
Nov 4, 2021·The FEBS Journal·Ines LiebscherSimone Prömel
Jul 5, 2021·Biological Chemistry·Isabell KaczmarekDoreen Thor

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