Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis

Cellular & Molecular Immunology
Ruonan XuFu-Sheng Wang

Abstract

Complement 5a (C5a) has been implicated in the pathogenesis of sepsis by inducing the functional impairment of neutrophils; however, the utility of C5a receptors (C5aRs; C5aR and C5L2) as biomarkers for the management of sepsis is uncertain. This study investigated the dynamic expression of C5aR and C5L2 on neutrophils and their effects on neutrophil function. We found that sepsis patients displayed low expression levels of C5aR and C5L2 on neutrophils compared to healthy and systemic inflammatory response syndrome (SIRS) subjects, and this expression pattern was correlated with disease severity. Additionally, the expression levels of C5aR and C5L2 were associated with the survival of sepsis patients. In vitro, the addition of C5a significantly reduced C5aR and C5L2 expression levels and IL-8 production in neutrophils from sepsis patients. Those findings suggest that the reduced expression of C5aRs was associated with the functional impairment of neutrophils and a poor prognosis for sepsis patients. Overall, these findings may help establish C5aRs expression levels as early markers to predict the severity of sepsis.

References

Nov 22, 2000·The Journal of Clinical Investigation·R F GuoP A Ward
Jul 11, 2001·Critical Care Medicine·D C Angus, R S Wax
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Markus S Huber-LangPeter A Ward
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
Aug 5, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ren-Feng GuoPeter A Ward
Aug 6, 2003·Biochemistry·Shoji OkinagaCraig Gerard
Sep 10, 2003·Journal of Leukocyte Biology·Niels C RiedemannPeter A Ward
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Markus Huber-LangPeter A Ward
Jan 25, 2005·Journal of Hepatology·Hermann E WasmuthFrank Lammert
Mar 28, 2009·American Journal of Respiratory and Critical Care Medicine·Andrew Conway MorrisA John Simpson
Jul 17, 2009·Critical Care : the Official Journal of the Critical Care Forum·Holger PoehlmannChristian Meisel
Dec 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rui LiTrent M Woodruff
Mar 13, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heike UnnewehrMarkus Huber-Lang
Jun 13, 2013·British Journal of Anaesthesia·A Conway MorrisA J Simpson
Sep 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ruobing WangNorma P Gerard

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Citations

Aug 1, 2016·The American Journal of Emergency Medicine·Ying-Ying FangChun-Sheng Li
Nov 9, 2016·Chinese Medical Journal·Fang ZhangShu-Bin Guo
Mar 6, 2018·Cellular & Molecular Immunology·Bo SunYong Zhao
Aug 8, 2017·Cellular & Molecular Immunology·Ruonan XuFu-Sheng Wang
Feb 6, 2020·Experimental and Therapeutic Medicine·Meirong ZhuShaoqin Wang
Jul 6, 2020·FEBS Letters·Tom E Mollnes, Markus Huber-Lang
Jun 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Quan-You ZhengShen-Ju Liang
Jul 15, 2017·Journal of Immunology Research·Ting ZhangKe Li
Sep 29, 2020·Frontiers in Immunology·Ebru KarasuRebecca Halbgebauer
Feb 27, 2020·Anesthesiology·Holger Müller-RedetzkyMartin Witzenrath
Apr 6, 2019·Frontiers in Immunology·Ebru KarasuMarkus Huber-Lang
Oct 8, 2020·Annals of Intensive Care·Axel NierhausMassimo Girardis
Oct 29, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C B ResendeM M Teixeira
Jun 1, 2021·Frontiers in Medicine·Dominik JarczakAxel Nierhaus
Jul 3, 2021·International Journal of Molecular Sciences·Marta Martín-FernándezEduardo Tamayo

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