Complement activation and C3 binding by serum-sensitive and serum-resistant strains of Pseudomonas aeruginosa.

Infection and Immunity
N L SchillerK Joiner

Abstract

The relationship among complement consumption, C3 deposition, and C3 fragmentation pattern was compared for serum-sensitive (Sers) and serum-resistant (Serr) strains of Pseudomonas aeruginosa. The Sers strains, which were mucoid strains derived from patients with cystic fibrosis, had lipopolysaccharide deficient in O-antigen side chains. These organisms generally activated much less complement per organism than their Serr counterparts, characterized by the presence of lipopolysaccharide with long lipopolysaccharide O side chains. Surprisingly, however, although the Serr strains consumed more total hemolytic complement, less C3 was deposited onto the surface of these strains than onto that of the Sers strains. Maximal C3 binding required the participation of both the classical and alternative complement pathways, although classical complement pathway involvement was more important for Serr strains. Finally, while more than half of the C3 deposited on most Sers strains was in the form of C3b, most of the C3 on the Serr strains was in the form of iC3b, indicating a more rapid and extensive conversion of C3b to iC3b on the surface of these strains. Limited complement activation by Sers mucoid strains of P. aeruginosa may confer a s...Continue Reading

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Citations

Dec 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander J LaarmanSuzan H M Rooijakkers
Jan 1, 1994·Springer Seminars in Immunopathology·M C Moffitt, M M Frank
Feb 21, 2008·Infection and Immunity·Elizabeth M GoebelEric T Harvill
Aug 1, 2007·Expert Review of Respiratory Medicine·Patricia J Dubin, Jay K Kolls
Jun 1, 1990·Journal of Clinical Microbiology·M FeganJ A Fuerst
Feb 1, 1992·Current Opinion in Immunology·M M Frank

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