PMID: 9647087Jul 1, 1998Paper

Complement activation and cytokine generation after modified Fontan procedure

The Annals of Thoracic Surgery
Richard D MainwaringT E Hugli

Abstract

The modified Fontan procedure separates the systemic and pulmonary circulations in patients born with a functional single ventricle. Delayed recovery is frequently observed after this procedure. It was our hypothesis that complement activation or cytokine generation may contribute to the pathophysiology of this problem. We measured activated complement C3, thromboxane B2, interleukin-6, and tumor necrosis factor-alpha levels by immunoassay in 16 patients undergoing Fontan procedure. Patient plasma samples were obtained preoperatively, on initiation of cardiopulmonary bypass, after administration of protamine, and 1, 4, 8, and 24 hours postoperatively. There was no early or late mortality in this cohort of patients. Low cardiac output developed in 3 of 16 patients, and pleural effusions developed in 5. The median length of hospital stay was 9 days. Activated complement C3 levels increased from a baseline of 1,486 +/- 564 to 4,600 +/- 454 ng/mL after cardiopulmonary bypass and administration of protamine, and returned to baseline by 24 hours. The level of interleukin-6 increased from 42 +/- 32 to 176 +/- 22 pg/mL and at 24 hours remained elevated at 71 +/- 15 pg/mL. Neither thromboxane B2 nor tumor necrosis factor-alpha levels in...Continue Reading

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Citations

Apr 10, 2003·The Annals of Thoracic Surgery·John M CostelloConstantine Mavroudis
Mar 10, 2001·Cardiology in the Young·A R MottG Wernovsky
Nov 1, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Stanislav OvroutskiMichael Hübler
Jul 1, 2008·Annals of Pediatric Cardiology·Sachin Khambadkone
Jul 6, 2000·The Annals of Thoracic Surgery·R A BronickiT P Green
Jul 6, 2000·The Annals of Thoracic Surgery·A WesselH Loppnow
Aug 10, 2010·Microfluidics and Nanofluidics·Lawrence A SassoJeffrey D Zahn
Sep 26, 2012·The Annals of Thoracic Surgery·Brent M GordonLeonard L Bailey
Dec 30, 2009·The Journal of Thoracic and Cardiovascular Surgery·Mohammad Ali NavabiReza Shabanian
Apr 10, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Elumalai AppachiPaula Bokesch
Jan 24, 2006·The Annals of Thoracic Surgery·Yoichi KawahiraToshikatsu Yagihara
Jan 4, 2012·Journal of the American College of Cardiology·Jeffrey A FeinsteinGerard R Martin
May 6, 2008·The Journal of Thoracic and Cardiovascular Surgery·Akio IkaiKisaburo Sakamoto
Jun 25, 2014·World Journal for Pediatric & Congenital Heart Surgery·Richard D MainwaringFrank L Hanley
Feb 3, 2019·Pediatric Cardiology·Stephanie A GoldsteinAlbert P Rocchini
Oct 1, 2018·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Sachin TalwarBalram Airan
Jul 29, 2021·The American Journal of Cardiology·Lauren N ManningJohn R Charpie

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