PMID: 8610533Jan 1, 1995Paper

Complement activation and histamine release following administration of roentgen contrast media

Acta Radiologica. Supplementum
H VikT Ege

Abstract

Anaphylactoid reactions following administration of reontgen contrast media (CM) have occasionally been described. In this investigation, blood samples for nonallergic human volunteers were exposed to the CM iodixanol (Visipaque), iohexol (Omnipaque), ioxaglate (Hexabrix) and metrizoate (Isopaque 350). The degree of activation of the complement cascade and the amount of free histamine in the samples were estimated. By using a hemolytic assay, a dose-independent complement consumption was detected when salt-free dilutions of the CM were added to human serum. Very little complement consumption was detectable when the concentrations, indicating that in the CM solutions were adjusted toward normal plasma concentrations, indicating that the lack of salts in the CM formulations was responsible for causing the consumption of complement rather than the CM molecules themselves. By using ELISA assay for determination of the terminal complement complex (TCC), no increase in TCC level was detected following the addition of iodixanol to human serum. The results indicate that iodixanol does not activate the complement cascade when added to human serum, and that it is unlikely that anaphylactoid reactions observed in man after CM administrati...Continue Reading

References

Oct 1, 1979·The Journal of Allergy and Clinical Immunology·F C CogenB Zweiman
Jan 1, 1978·International Archives of Allergy and Applied Immunology·G TillD Gemsa
May 1, 1990·Journal of the American Academy of Dermatology·M KiefferE Svejgaard
Mar 1, 1986·The American Journal of Medicine·D N SalemP F Cohen
Nov 1, 1986·Allergy·F EbbesenI Søndergaard
Apr 1, 1987·Agents and Actions·P Stahl SkovH Nolte
Apr 1, 1988·Agents and Actions·H Nolte, P Stahl Skov
Jan 1, 1988·International Archives of Allergy and Applied Immunology·L K PoulsenB Weeke
Jan 1, 1988·The American Journal of Pediatric Hematology/oncology·H NolteH Hertz
Jan 1, 1989·Advances in Experimental Medicine and Biology·H M HoffmeisterW Heller
Sep 1, 1971·Radiology·E C LasserJ Lang
Sep 1, 1983·The British Journal of Radiology·E S AssemP Dawson
Apr 1, 1984·Agents and Actions·P Stahl SkovB Weeke
Jan 1, 1983·Acta Radiologica: Diagnosis·K Måre, M Violante

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Citations

Dec 19, 2003·Current Allergy and Asthma Reports·Janos Szebeni
Feb 23, 2013·Emergency Radiology·Jennifer G SchoppManjiri K Dighe
Apr 24, 2010·Fundamental & Clinical Pharmacology·Ingrid BöhmHans H Schild
Apr 16, 1998·The British Journal of Radiology·P T Peachell, S K Morcos

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