PMID: 8972696Dec 4, 1996Paper

Complement activation in human serum by liposome-encapsulated hemoglobin: the role of natural anti-phospholipid antibodies

Biochimica Et Biophysica Acta
J SzebeniC R Alving

Abstract

In exploring the occurrence and mechanism of liposome-encapsulated hemoglobin (LEH)-induced complement (C) activation, we found that normal human serum contained low titers of IgG and IgM class natural antibodies with reactivity against LEH, and that the amount of vesicle-bound IgM significantly correlated with LEH-induced C consumption. IgM binding to LEH was inhibited by phosphocholine and ATP, but not by choline chloride. These data suggest that naturally occurring antibodies play a key role in LEH-induced C activation, and that a major portion of these antibodies are directed against the phosphate moiety on the phospholipid headgroups of liposome bilayers.

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Citations

Aug 1, 1997·The Journal of Laboratory and Clinical Medicine·C R Alving, J Szebeni
Jun 6, 2000·Advanced Drug Delivery Reviews·E MastrobattistaG Storm
Nov 10, 2006·Critical Reviews in Food Science and Nutrition·Yan Xianghua, Xu Zirong
Aug 15, 1998·Vox Sanguinis·T E Mollnes
Feb 28, 2009·Pharmaceutical Research·Wim JiskootHuub Schellekens
Feb 5, 2002·Biochimica Et Biophysica Acta·Sandor SavayCarl R Alving
Jun 27, 2006·Journal of Immunotherapy·Bernard J ScallonMarian T Nakada
Oct 1, 2005·Journal of Liposome Research·Xuedong YanJan A A M Kamps
Mar 8, 2006·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Hideki AbeHideyoshi Harashima
Apr 25, 2007·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Hideki AbeEishun Tsuchida
May 16, 1998·Autoimmunity·H M Cheng
Mar 4, 1999·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·J Szebeni, C R Alving
Oct 27, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S Moein MoghimiJanos Szebeni
Oct 24, 2018·Nature Nanotechnology·Janos SzebeniMarina A Dobrovolskaia
Jul 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Barry W NeunMarina A Dobrovolskaia

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