Complement Activation in Patients with Focal Segmental Glomerulosclerosis

PloS One
Joshua M ThurmanHoward Trachtman

Abstract

Recent pre-clinical studies have shown that complement activation contributes to glomerular and tubular injury in experimental FSGS. Although complement proteins are detected in the glomeruli of some patients with FSGS, it is not known whether this is due to complement activation or whether the proteins are simply trapped in sclerotic glomeruli. We measured complement activation fragments in the plasma and urine of patients with primary FSGS to determine whether complement activation is part of the disease process. Plasma and urine samples from patients with biopsy-proven FSGS who participated in the FSGS Clinical Trial were analyzed. We identified 19 patients for whom samples were available from weeks 0, 26, 52 and 78. The results for these FSGS patients were compared to results in samples from 10 healthy controls, 10 patients with chronic kidney disease (CKD), 20 patients with vasculitis, and 23 patients with lupus nephritis. Longitudinal control of proteinuria and estimated glomerular filtration rate (eGFR). Levels of the complement fragments Ba, Bb, C4a, and sC5b-9 in plasma and urine. Plasma and urine Ba, C4a, sC5b-9 were significantly higher in FSGS patients at the time of diagnosis than in the control groups. Plasma Ba l...Continue Reading

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Citations

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Aug 31, 2021·American Journal of Physiology. Renal Physiology·Howard TrachtmanJoshua M Thurman

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Methods Mentioned

BETA
electron microscopy
biopsy
enzyme linked immunosorbent assays
ELISAs
biopsies

Software Mentioned

GraphPad Prism

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