Complement activation in patients with immune thrombocytopenic purpura according to phases of disease course.

Clinical and Experimental Immunology
R CastelliL Bergamaschini

Abstract

Immune thrombocytopenic purpura (ITP) is an autoimmune thrombocytopenia with shortened platelet survival and relative bone marrow failure. The pathogenesis involves antibody production, cytokine release, T cell impairment, complement activation and clearance of platelets. We measured plasma levels of C3, C4, C1q and sC5b-9 in 80 ITP patients in acute phase, 50 ITP patients in complete (CR) or partial (PR) remission and 50 age- and sex-matched healthy volunteers. Statistical analyses showed that acute ITP patients had higher plasma levels of sC5b-9 and C1q than CR or PR patients (median = sC5b-9: 200 versus 98 mg/dl, P-value < 0·001) (median C1q = 2·11 versus 1·00 mg/dl, P-value < 0·001). CR and PR ITP patients had sC5b-9 and C1q plasma levels comparable to those observed in healthy volunteers. There was a significant correlation between sC5b-9 and C1q plasma levels (Spearman's rho correlation index on 130 ITP patients equal to 0·58, P-value < 0·001). We also found that sC5b-9 plasma level is inversely correlated with the number of platelets. Furthermore, we divided acute ITP patients into subjects with detectable (24 of 80, 30%) or undetectable (56 of 80, 70%) anti-platelet antibodies; patients with detectable anti-platelet ant...Continue Reading

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Citations

Feb 9, 2021·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Roberto CastelliGiorgio Lambertenghi Deliliers
Mar 9, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Solomon GetawaTiruneh Adane
Apr 4, 2021·Journal of Clinical Medicine·Sylvain Audia, Bernard Bonnotte
May 1, 2021·Journal of Clinical Medicine·Andrés Ramírez-LópezNora V Butta
Jun 8, 2021·HemaSphere·Sylvain AudiaBernard Bonnotte

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