Complement activation in patients with sepsis is in part mediated by C-reactive protein

The Journal of Infectious Diseases
G J WolbinkC E Hack

Abstract

The involvement of C-reactive protein (CRP) in the activation of complement in patients with sepsis was investigated. In 104 patients with infections of varying severity, circulating levels of CRP-complement complexes, which are specific indicators for CRP-mediated complement activation, were assessed. Complement-CRP complexes were increased in almost all patients and correlated significantly with levels of C3a (r = .59; P < .001) and C-reactive protein (r = .76; P < .001). In addition, they correlated with levels of secretory phospholipase A2 (r = .59; P < .001). Levels of complement-CRP complexes in patients with a pneumococcal type of infection were similar to those in patients with other types of infections. Complement-CRP complexes were significantly higher in patients with shock (P = .01) and in patients who died (P = .03). These results demonstrate that part of the complement activation in patients with sepsis is independent from a direct interaction with microorganisms but rather results from an endogenous mechanism involving CRP.

Citations

Apr 26, 2013·Immunologic Research·Eleonora BallantiRoberto Perricone
Sep 8, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Alegria LevyJesús Mosquera
Apr 4, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·A B J GroeneveldC E Hack
Jul 11, 2001·Critical Care Medicine·C E Hack, S Zeerleder
May 11, 2002·Critical Care Medicine·Steven M OpalSigurd Knaub
May 4, 2002·The Journal of Trauma·Weiyang WangDanny O Jacobs
Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·A B GroeneveldC E Hack
Oct 7, 2004·Biological & Pharmaceutical Bulletin·Eric Brian HoieTerrence Leo Zach
Oct 20, 2006·Molecular Immunology·Chantal Dumestre-PérardMichael Loos
Nov 12, 2005·British Journal of Haematology·Charles T Esmon
Oct 28, 2004·Thrombosis Research·Charles T Esmon
Jun 1, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Rita S JerathGregory G Passmore
Mar 4, 2014·Orthopaedics & Traumatology, Surgery & Research : OTSR·C Ronde-OustauJ-M Lessinger
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Okom Nkili F C Ofodile
Oct 30, 2013·ISRN Inflammation·Terry W Du Clos
Feb 18, 2005·Acta Anaesthesiologica Scandinavica·R SarbinowskiA Bengtsson
Jun 25, 2005·Journal of Medical Virology·Albert T A MairuhuEric C M van Gorp
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·C T Esmon
Jul 23, 2003·Immunology·Niubel Diaz PadillaC Erik Hack
Aug 20, 2010·Immunological Investigations·Koen J Hartemink, A B Johan Groeneveld
Mar 13, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heike UnnewehrMarkus Huber-Lang
Sep 25, 2003·Physiological Reviews·Bjarne Osterud, Eirik Bjorklid
Mar 25, 2005·Biochemical Society Transactions·C T Esmon
Mar 30, 2021·Orthopaedics & Traumatology, Surgery & Research : OTSR·César PrazChristophe Hulet
Oct 21, 2000·Biochimica Et Biophysica Acta·A J AarsmanH van den Bosch
May 13, 2011·The Journal of Physical Chemistry. B·Jesper J MadsenGünther H Peters

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