Complement activation is involved in the structural deterioration of bovine pericardial bioprosthetic heart valves

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
M MoczarD Loisance

Abstract

Disintegrated collagen fibers surrounded with protein deposits are a morphologic feature in torn, folded, and disrupted cusps of pericardial prostheses explanted for clinical dysfunction. New technologies for valve bioprostheses with improved durability require further investigation of molecular mechanisms initiating the deterioration of bioprosthetic valves. The authors' aim was to obtain experimental evidence of biologic factors contributing to the degradation of the bioprosthetic matrix. Clinically failed Mitroflow (22), Hancock (3), Ionescu-Shiley (2), and Sorin (1) valves were explanted after 69-170 months. Non calcific deterioration of the prosthetic matrix was studied with labeled antibodies to plasma proteins and cells. IgG, and complement proteins C1q, C3, and C4 were accumulated close to dissociated collagen bundles (26/28) throughout the prostheses. Fibrin was identified on the cuspal surface and in the deep disrupted areas. The fibrin peptides and proteolytic breakdown products of the complement components, the latter consistent with complement activation and chemotaxis for monocytes, were shown by immunoenzymic assay on Western blots from the valve extracts. The complement activation triggered by the IgG aggregates...Continue Reading

Citations

Feb 13, 2001·Journal of Biomechanics·T C LeeI Vesely
May 24, 2011·Seminars in Immunopathology·Werner Zimmerli, Parham Sendi
Jun 25, 1998·Journal of Biomedical Materials Research·L TangH B Elwing
Jun 16, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jonathan T Butcher, Robert M Nerem

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