Complement activation on degraded polyethylene glycol-covered surface

Acta Biomaterialia
Mitsuaki TodaHiroo Iwata

Abstract

Surface modification with polyethylene glycol (PEG) has been employed in the development of biomaterials to reduce unfavorable reactions. However, unanticipated body reactions have been reported, with activation of the complement system being suggested as having involvement in these responses. In this study, we prepared a PEG-modified surface on a gold surface using a monolayer of alpha-mercaptoethyl-omega-methoxy-polyoxyethylene. We observed neither protein adsorption nor activation of the complement system on the PEG-modified surface just after preparation. Storage of the PEG-modified surface in a desiccator under ambient light for several days or following ultraviolet irradiation, reflection-adsorption (FTIR-RAS) and X-ray photo spectrometry revealed deterioration of the PEG layer, which became a strong activator of the complement system through the alternative pathway.

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May 17, 2003·Nature Reviews. Drug Discovery·Ruth Duncan
Mar 7, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
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Apr 3, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·XinYu WangHiroshi Kiwada
Oct 24, 2007·Biomaterials·Mitsuaki TodaHiroo Iwata
Nov 6, 2007·Biomaterials·Yusuke ArimaHiroo Iwata

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Citations

Jul 24, 2013·Advanced Drug Delivery Reviews·Anne Mari A RokstadBerit L Strand
Aug 2, 2011·Advanced Drug Delivery Reviews·Yusuke ArimaHiroo Iwata
Jun 15, 2011·Current Opinion in Chemical Biology·Luisa Mayorga Szott, Thomas A Horbett
Sep 27, 2014·Journal of Biomedical Materials Research. Part a·Ru FengChangren Zhou
Jan 5, 2011·Acta Biomaterialia·Qian YuHong Chen

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