PMID: 8964911May 1, 1996Paper

Complement activation on human neuroblastoma cell lines in vitro: route of activation and expression of functional complement regulatory proteins

Journal of Neuroimmunology
P GasqueB P Morgan

Abstract

Two human neuroblastoma cell lines activated the classical pathway of complement in serum. Activation caused the opsonisation of these cells with complement fragments but with moderate cell killing. Neuroblastoma expressed regulators MCP and CD59 but did not express DAF or CR1. Neutralisation of CD59 rendered the cells susceptible to killing. Neuroblastoma also expressed C1-inhibitor, factor H, clusterin and S-protein. Expression of several regulators was enhanced by incubation with cytokines. Complement inhibition using soluble CRI markedly reduced opsonisation and killing of neuroblastoma. Our results suggest that complement might play a role in neuronal loss and that treatment with complement inhibitors might be of therapeutic value.

References

Dec 1, 1992·Journal of Neuroscience Methods·D L GordonT A Sadlon
Jun 1, 1992·Brain Research. Molecular Brain Research·D G Walker, P L McGeer
Nov 1, 1992·Experimental Neurology·G M PasinettiC E Finch
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J RogersP Ward
Aug 1, 1989·Brain : a Journal of Neurology·C LiningtonD A Compston
Dec 15, 1989·Neuroscience Letters·P L McGeerE G McGeer
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P EikelenboomF C Stam
Jul 1, 1989·Neuropathology and Applied Neurobiology·D A CompstonB Jasani
Jan 1, 1995·Critical Reviews in Clinical Laboratory Sciences·B P Morgan
Jul 1, 1994·European Journal of Immunology·L BjørgeR Matre
Jan 1, 1995·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·S R Barnum
Oct 6, 1994·Nature·H R Colten
Apr 1, 1994·European Journal of Clinical Investigation·B P Morgan
Nov 1, 1993·The Pediatric Infectious Disease Journal·R B Johnston
Jun 1, 1993·Immunology and Cell Biology·V M AveryD L Gordon
Jan 1, 1996·Acta Neuropathologica·R VeerhuisP Eikelenboom

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Citations

Mar 4, 2000·Molecular Immunology·K JurianzM Kirschfink
Aug 27, 1998·Neuroscience Letters·D G Walker, P L McGeer
Jan 10, 2002·Journal of Neurotrauma·B M BellanderM Svensson
Oct 28, 2003·Journal of Neurotrauma·Marcus OhlssonMikael Svensson
Sep 17, 2013·International Immunology·Brady MichelMark D Zabel
May 1, 1997·Australian and New Zealand Journal of Ophthalmology·J LanG D Jackson
Aug 26, 2004·Journal of Neuroinflammation·Masato HosokawaPatrick L McGeer
Sep 19, 2009·Neuromolecular Medicine·Trent M WoodruffStephen M Taylor
May 7, 2011·Molecular Immunology·Robert VeerhuisAndrea J Tenner
Sep 4, 2009·Journal of Cellular and Molecular Medicine·Rossen DonevJohannes Thome
Jun 10, 2003·Annals of the New York Academy of Sciences·Johan van BeekPhilippe Gasque
May 28, 2013·Seminars in Immunology·Ruben PioJohn D Lambris
Jul 23, 2015·Journal of Biomedical Science·M Afzal KhanD C Broering
Jan 27, 2015·Annual Review of Immunology·Seng-Ryong WooThomas F Gajewski
Jan 22, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Adrian J MaurerMichael E Sughrue
Aug 8, 2009·Progress in Brain Research·V Ramaglia, F Baas
Jun 17, 2006·Circulation Research·J MoccoE Sander Connolly
Jul 20, 2007·Scandinavian Journal of Immunology·E D PedersenT E Mollnes
Aug 25, 2001·The British Journal of Nutrition·H CrewsG Williamson
Sep 18, 2010·Expert Opinion on Therapeutic Targets·Jean-Laurent DevilleLaurent Daniel
Jun 18, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yosra BedouiPhilippe Gasque
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giovanna VinciMario Tosi
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susmit SuvasBarry T Rouse
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S JunnikkalaS Meri
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Johan van BeekPhilippe Gasque
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel AjonaRuben Pio
Apr 20, 2019·Frontiers in Immunology·Daniel AjonaFernando Lecanda
Feb 19, 2021·The FEBS Journal·Oluwaseun FatobaToshihide Yamashita

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