Complement activation on platelets: implications for vascular inflammation and thrombosis.

Molecular Immunology
Ellinor I PeerschkeBerhane Ghebrehiwet

Abstract

Platelets participate in a variety of responses of the blood to injury. An emerging body of evidence suggests that these cells express an intrinsic capacity to interact with and trigger both classical and alternative pathways of complement. This activity requires cell activation with biochemical agonists and/or shear stress, and is associated with the expression of P-selectin, gC1qR, and chondroitin sulfate. Platelet mediated complement activation measurably increases soluble inflammatory mediators (C3a and C5a). Platelets may also serve as targets of classical complement activation in autoimmune conditions such as antiphospholipid syndromes (APS) and immune thrombocytopenia purpura (ITP). Retrospective correlation with clinical data suggests that enhanced platelet associated complement activation correlates with increased arterial thrombotic events in patients with lupus erythematosus and APS, and evidence of enhanced platelet clearance from the circulation in patients with ITP. Taken together, these data support a role for platelet mediated complement activation in vascular inflammation and thrombosis.

Citations

Aug 6, 2011·Seminars in Immunopathology·Adriana Vieira-de-AbreuGuy A Zimmerman
Jul 9, 2011·Nature Medicine·Costantino Iadecola, Josef Anrather
Sep 19, 2012·Nature Reviews. Nephrology·Marina NorisGiuseppe Remuzzi
Aug 8, 2012·Nature Reviews. Rheumatology·Eric BoilardPeter A Nigrovic
Dec 29, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Markus BosmannPeter A Ward
Apr 12, 2011·Thrombosis and Haemostasis·Alan T Nurden
Nov 10, 2013·Future Microbiology·Cornelia SpethGünter Rambach
Apr 24, 2013·Blood·Anita HillPeter Hillmen
Jul 12, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lindsay S Keir, Moin A Saleem
Mar 6, 2016·Journal of the Neurological Sciences·Julio C FurlanFrank L Silver
Dec 21, 2011·The Journal of Physiology·Karen Y Stokes, D Neil Granger
Jan 1, 2014·Antioxidants·Rachel ShirleyLorraine M Work
May 30, 2013·Hematology/oncology Clinics of North America·Gaurav Kistangari, Keith R McCrae
Nov 1, 2011·Thrombosis Research·Nicoleta AlexandruAdriana Georgescu
Dec 5, 2015·Frontiers in Immunology·Katharina Andrea SchuettMathias Burgmaier
Jul 6, 2014·Thrombosis and Haemostasis·Cornelia SpethCornelia Lass-Flörl
Aug 22, 2015·Thrombosis and Haemostasis·Mark R Thomas, Robert F Storey
Feb 13, 2013·American Journal of Reproductive Immunology : AJRI·Shanmugam VelayuthaprabhuGovindaraju Archunan
Jun 20, 2014·Journal of Thrombosis and Haemostasis : JTH·M RuggeriUNKNOWN Gruppo Italiano Malattie EMatologiche dell'Adulto (GIMEMA) Anemia and Thrombocytopenias Working Party. GIMEMA Study ITP0311
Aug 26, 2015·British Journal of Haematology·Ellinor I B PeerschkeJames Bussel
Jun 16, 2015·Molecular Immunology·David A RubensteinWei Yin
Apr 9, 2015·European Journal of Clinical Investigation·Mira MerashliMunther Khamashta
Jul 8, 2015·Journal of Thrombosis and Haemostasis : JTH·E M Conway
Aug 31, 2011·Autoimmunity·Valentina CantiPatrizia Rovere-Querini
Jun 8, 2013·European Journal of Internal Medicine·Seppo Meri
Apr 19, 2015·Molecular Immunology·Cornelia SpethKristina N Ekdahl
Mar 24, 2015·Frontiers in Immunology·Henry M NordingHarald F Langer
Feb 27, 2015·Acta Neuropathologica·Ari WaismanTommy Regen
Jul 22, 2014·Molecular Immunology·Ellinor I B Peerschke, Berhane Ghebrehiwet
Mar 15, 2015·Frontiers in Immunology·Hind Hamzeh-CognasseOlivier Garraud
Nov 22, 2014·Frontiers in Immunology·Christine GaboriaudVéronique Rossi
Jun 18, 2016·Scandinavian Journal of Immunology·Z HorváthR G Kiss
Oct 23, 2016·Seminars in Immunology·Carsten Deppermann, Paul Kubes
Oct 26, 2016·Thrombosis Research·Rong FuZonghong Shao
Oct 27, 2016·Immunological Reviews·Adam Z BlattViviana P Ferreira

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