PMID: 6170591Jan 1, 1981Paper

Complement activation requirements for histamine release from human leukocytes: influence of purified C3ahu and C5ahu on histamine release

International Archives of Allergy and Applied Immunology
C T Hartman, M M Glovsky

Abstract

The activation of human sera for histamine release by zymosan and anti-BSA-BSA complexes at equivalence was dose dependent and associated with a marked fall in CH50, C3 and C5 hemolytic activities. Heat-aggregated IgG, though able to fix greater than 90% of human CH50 activity and produce a lesser fall in C3 and C5 activities than zymosan and BSA-anti-BSA complexes, was unable to induce basophil histamine release. Chemically purified human C3a and C5a each caused histamine release from human basophils; C5a was more potent than C3a. In addition, neither zymosan nor BSA-anti-BSA complexes released histamine when incubated with homozygous C3-deficient serum. The addition of C3a and C5a at suboptimal concentrations produced an additive effect of histamine release.

Citations

Aug 1, 1983·Agents and Actions·H Bult, A G Herman
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S C BischoffC A Dahinden
Jan 30, 1999·The British Journal of Ophthalmology·J I McGillA Bacon
Feb 1, 1990·Clinical Immunology and Immunopathology·A MiadonnaC Zanussi
Sep 14, 2011·International Archives of Allergy and Immunology·Krisztina Kosina-HagyóJános Németh
Feb 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·N W LukacsP A Ward
Mar 1, 1985·The American Journal of the Medical Sciences·M D Tharp

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