Complement and immunity to viruses

Immunological Reviews
P J Lachmann, A Davies

Abstract

Complement is one of the first lines of host defence to be faced and countered by viruses as they struggle to establish an infection. As an important arm of the humoral immune response, the complement system is immediately ready to target and eliminate virus particles and to interact with the surface of virus-infected cells to mark them for destruction by other branches of the immune response. Nevertheless, some viruses are still very successful human pathogens. This article will discuss the role of complement in antiviral immunity, the mechanisms by which complement may be activated by viruses or virus-infected cells, and explore some of the strategies which viruses have evolved to subvert the immune response, including mechanisms by which complement activation may be prevented or aborted.

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A F EsserH J Müller-Eberhard
Oct 1, 1975·The Journal of Experimental Medicine·B S Joseph, M B Oldstone
Jun 1, 1992·Journal of Virology·J C Albrecht, B Fleckenstein
Aug 1, 1992·Journal of Virology·J C AlbrechtB Fleckenstein
Dec 1, 1992·The Journal of Infectious Diseases·R McKenzieM M Frank
Jul 1, 1992·Journal of Virology·S L HungG H Cohen
Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S N IsaacsB Moss
May 1, 1990·Journal of Virology·C Seidel-DuganG H Cohen
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R FradeG Klein
Jul 1, 1968·The Journal of General Virology·D M Berry, J D Almeida
Dec 1, 1984·The Journal of Experimental Medicine·L F FriesM M Frank
Jan 1, 1984·Springer Seminars in Immunopathology·P J Lachmann, N C Hughes-Jones
Mar 1, 1980·Clinical Immunology and Immunopathology·R D SchreiberH J Müller-Eberhard
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J G SissonsR D Schreiber
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·M ManchesterM B Oldstone
Mar 1, 1993·Immunopharmacology·N ThieblemontN Haeffner-Cavaillon
Jul 1, 1996·Journal of Virology·H M FriedmanJ Lubinski
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·J J RussoP S Moore

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Citations

Jan 5, 2011·Archives of Virology·D KaulitzJ Denner
Dec 15, 2000·Immunology Today·A F Ochsenbein, R M Zinkernagel
Aug 28, 2003·Microbes and Infection·Lance R DunlopAriella M Rosengard
Nov 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nicole JollerAnnette Oxenius
Oct 19, 1999·The Journal of Experimental Medicine·A F OchsenbeinR M Zinkernagel
Jun 3, 2000·Annual Review of Immunology·D TortorellaH L Ploegh
Jul 19, 2013·PloS One·Keita MatsubaraTetsuo Nakayama
Aug 29, 2013·Developmental and Comparative Immunology·Bertrand Collet
May 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ariella M RosengardRobert Jimenez
Jul 15, 2004·International Immunopharmacology·Matthias BudtHartmut Hengel
Jul 6, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Vicente CastroHarald Takle
Sep 27, 2019·Immunological Reviews·Liriye KurtovicJames G Beeson
Dec 24, 2019·PLoS Pathogens·Stéphanie BibertPierre-Yves Bochud
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter AichelePeter Seiler
Apr 16, 2019·Journal of Proteome Research·Jianing ChenGuangliang Liu
Jun 17, 2021·The Journal of Infectious Diseases·Iris D BrinkmanDebbie van Baarle

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