Complement C3 and High Risk of Venous Thromboembolism: 80517 Individuals from the Copenhagen General Population Study

Clinical Chemistry
Ina NørgaardB G Nordestgaard

Abstract

Complement activation may contribute to venous thromboembolism, including deep venous thrombosis and pulmonary embolism. We tested the hypothesis that high complement C3 concentrations are associated with high risk of venous thromboembolism in the general population. We included 80 517 individuals without venous thromboembolism from the Copenhagen General Population Study recruited in 2003-2012. Plasma complement C3 concentrations were measured at baseline, and venous thromboembolism (n = 1176) was ascertained through April 2013 in nationwide registries. No individuals were lost to follow-up. Complement C3 concentrations were approximately normally distributed, with a mean value of 1.13 g/L (interquartile range 0.98-1.26; SD 0.21). The cumulative incidence of venous thromboembolism was higher with progressively higher tertiles of complement C3 (log-rank trend: P = 3 × 10(-8)): at age 80, 7%, 9%, and 11% of individuals in the first, second, and third tertiles, respectively, had developed venous thromboembolism. Multivariable-adjusted hazard ratios for venous thromboembolism compared with individuals in the first tertile were 1.36 (95% CI, 1.16-1.59) for those in the second tertile and 1.58 (1.33-1.88) for those in the third tert...Continue Reading

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Citations

Mar 29, 2019·Journal of Thrombosis and Haemostasis : JTH·Ina I HøilandJohn-Bjarne Hansen
Jun 21, 2019·Journal of Thrombosis and Haemostasis : JTH·Robin A LiangJohn-Bjarne Hansen
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Mar 3, 2020·Clinical Hemorheology and Microcirculation·Melania CarlisiSergio Siragusa
Mar 15, 2020·International Journal of Molecular Sciences·Clemens GutmannAlberto Smith
Feb 21, 2018·Shock·Martijn van GriensvenMarkus Huber-Lang
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Apr 6, 2021·British Journal of Pharmacology·Elias RawishHarald F Langer
Jun 11, 2021·Circulation Research·Meaghan E CollingYogendra Kanthi
Nov 26, 2021·Blood·Kristen M Sanfilippo
Dec 24, 2021·Hämostaseologie·Nadine GauchelDaniel Duerschmied

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