Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection

Medical Microbiology and Immunology
Thomas JacobsJoachim Clos

Abstract

To elucidate the role of complement-mediated uptake in Leishmania major infection in vivo, transgenic BALB/c mice that express the cobra venom factor (CVF) under control of the alpha1-antitrypsin promoter were infected. CVF expression in these mice leads to a continuous activation and subsequent consumption of complement C3 in the serum. In contrast to susceptible non-transgenic BALB/c mice, CVF-transgenic mice are highly resistant to L. major infection and show a significantly reduced parasite dissemination. Transient depletion of C3 in wild-type BALB/c mice delays progression of lesions for some days. Both CVF-transgenic and non-transgenic mice exhibit similar T cell responses upon infection. However, in CVF-transgenic mice, no infiltration of neutrophils, which were the prominent infiltrating cells at the site of infection in normal susceptible mice, could be detected. We conclude that C3 cleavage is required for the attraction of neutrophils that participate in parasite dissemination.

References

Feb 15, 1991·Journal of Immunological Methods·C W Van den BergH Van Dijk
Jan 1, 1988·Molecular and Biochemical Parasitology·G Chaudhuri, K P Chang
Oct 12, 1984·Journal of Immunological Methods·C W Vogel, H J Müller-Eberhard
Sep 15, 1995·The Journal of Immunology : Official Journal of the American Association of Immunologists·A BrittinghamD M Mosser
Jan 1, 1996·Advances in Experimental Medicine and Biology·C W VogelM A Kock
Jan 1, 1997·Parasitology·D M Mosser, A Brittingham
May 15, 1999·Journal of Clinical Microbiology·A PahlA Gessner
Aug 24, 1999·Infection and Immunity·A BrittinghamD M Mosser
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F Tacchini-CottierJ A Louis
Feb 19, 2002·Molecular and Biochemical Parasitology·Phalgun B JoshiW Robert McMaster
Feb 21, 2002·The Journal of Experimental Medicine·Mercedes DomínguezAlfredo Toraño
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eresso AgaTamás Laskay
Sep 11, 2002·Molecular Immunology·Jörg AndräDieter Paul

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Citations

Nov 4, 2009·Journal of Biomedicine & Biotechnology·Mélanie CharmoyFabienne Tacchini-Cottier
Aug 5, 2009·Medical Microbiology and Immunology·Tim LögtersMartin Scholz
Mar 6, 2016·Trends in Parasitology·Benjamin P HurrellFabienne Tacchini-Cottier
Sep 24, 2015·Acta Tropica·Norbert Georg SchwarzHagen Frickmann
Jul 11, 2012·Tropical Medicine & International Health : TM & IH·Hagen FrickmannSven Poppert
Jul 27, 2014·Molecular Immunology·Carl-Wilhelm VogelDavid C Fritzinger
Jun 11, 2016·Medical Microbiology and Immunology·Eugenia BifeldJoachim Clos
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanna Lopez KostkaEsther von Stebut
Mar 19, 2021·Frontiers in Immunology·Katiuska PasselliFabienne Tacchini-Cottier

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