Complement C3 proteins in psoriasis

The British Journal of Dermatology
F Acevedo, H Hammar

Abstract

A new polymorphism of the complement factor C3 in human plasma was demonstrated by isotachophoresis in agarose gels followed by immunodetection with rabbit anti-human C3c and C3d immunoglobulins. Four bands were detected in the immunoprint of freshly drawn EDTA-plasma, which were C3s1, C3s2, C3f1 and C3f2. At least four additional C3 components in Mg2+ -zymosan activated plasma were present, which were C3b1 to C3b4. The different forms of C3 in frozen and thawed heparin-plasma from 20 patients with psoriasis and 20 healthy individuals were studied from the immunoprint. The total content of C3 components was 29% greater in the patients with psoriasis than controls. The major difference was in the C3b components which were increased by 46%. In psoriatic patients, the two slow C3 components C3s1 and C3s2 were increased by 24 and 56% respectively, when compared with controls. The two fast C3 components C3f1 and C3f2 were decreased to 29 and 37%. The results suggest a direct involvement of the complement factor C3 in psoriasis.

References

Dec 1, 1978·The Journal of Pediatrics·R H McLeanN Rothfield
Jul 1, 1985·The Journal of Investigative Dermatology·D T Fearon
Jan 1, 1985·Immunogenetics·P H KayR L Dawkins
Jan 1, 1972·Human Heredity·J DissingH Sorensen
Jul 1, 1984·Molecular Immunology·E R Podack, J Tschopp
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A S WhiteheadG Fey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

Related Papers

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Sanjeev SethiRichard J H Smith
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
J DammanM A Seelen
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Navdeep DhillonBernd Schröppel
© 2022 Meta ULC. All rights reserved